DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Krt17

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_997710.1	Gene:	Krt17 / 287702	RGDID:	1303181	Length:	433	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	109/411 - (26%)
Similarity:	179/411 - (43%)	Gaps:	77/411 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||..:||||||||:|:|:||.||..|:.|.:::   ||...::
  Rat    84 EKATMQNLNDRLASYLDKVRALEEANTELEVKI---RDWYQKQ---------------------- 123

  Fly   119 ARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNE 183
            |...||   |....::..|:||||:...|.:..:....:......|::...|:....|.|..:..
  Rat   124 APGPAR---DYSAYYQTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEA 185

  Fly   184 DLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTE 248
            |:|              ..|:.|::.||:|.|||..|::|:|||::..:.|.:|:|..|
  Rat   186 DIN--------------GLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALR------ 230

  Fly   249 YSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTH 309
             .::.|.::.|.||    .|.:.|.|:|.|||:..:.||.:.:..:..|.:.|....|..|....
  Rat   231 -GQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQ 294

  Fly   310 KSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREE 374
            ....|:...|..:.||...:.......|.|...:.:.|.:......:....|..:|::|.:||.|
  Rat   295 SGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCE 359

  Fly   375 MTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRR 439
            |.||.:||:.|:|:|..|:.|||.|.:||.||:|.|                     |:..|..
  Rat   360 MEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL---------------------TQYKPKE- 402

  Fly   440 TPSAAVKRKRAVVDESEDHSV 460
              ....::.|.:|:|.:|..|
  Rat   403 --PVTTRQVRTIVEEVQDGKV 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	100/358 (28%)
		Ax_dynein_light	<283..377	CDD:287215	19/93 (20%)
		LTD	466..572	CDD:279300
Krt17	NP_997710.1	Head	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Filament	84..394	CDD:278467	100/358 (28%)
		Coil 1A. /evidence=ECO:0000255	84..120		20/38 (53%)
		Linker 1. /evidence=ECO:0000255	121..138		4/41 (10%)
		Coil 1B. /evidence=ECO:0000255	139..230		28/104 (27%)
		Zinc_peptidase_like	<215..296	CDD:301362	22/87 (25%)
		Linker 12. /evidence=ECO:0000255	231..250		4/18 (22%)
		Coil 2. /evidence=ECO:0000255	251..392		41/140 (29%)
		Tail. /evidence=ECO:0000255	393..433		9/53 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000