DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and Krt14

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001008751.1	Gene:	Krt14 / 287701	RGDID:	1307463	Length:	485	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	119/404 - (29%)
Similarity:	188/404 - (46%)	Gaps:	77/404 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRE-TTNIKNIFEAELLETRRLLD 116
            :|||.:||||||||||:|:||.||..||.|.:::   ||...|: .|.||
  Rat   121 SEKVTMQNLNDRLATYLDKVRALEEANSDLEVKI---RDWYQRQRPTEIK--------------- 167

  Fly   117 DTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKL 181
                       |....::..|:||:|:...|.:.......:......|::...|:....:.|..:
  Rat   168 -----------DYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLRINV 221

  Fly   182 NEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQ 246
            ..|:|              ..|:.|::.||:|.|||..|:||:|||::..:.|.:|:...|
  Rat   222 ESDIN--------------GLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMR---- 268

  Fly   247 TEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTS-- 305
               .::.|.::.|.||    .|.:.|.|:|.|||:..:.||.:.:..:..|.:.|....|..|
  Rat   269 ---GQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFTKTEELNREVATNSEL 330

  Fly   306 -NSTHKSIEELRSTRVRIDALNANINELE-QANADLNARIRDLERQLDNDRERHGQE-------I 361
             .|....|.|||.|...:        |:| |:...:.|   .||..|:..:.|:..:       |
  Rat   331 VQSGKSEISELRRTMQNL--------EIELQSQLSMKA---SLENNLEETKGRYCMQLAQIQEMI 384

  Fly   362 DLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ 426
            ..:|::|.:||.||.||.:||:.|:|:|..|:.|||.|.:||.||:|.|:....::::...|.||
  Rat   385 GSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQFSSGSQ 449

  Fly   427 SLRNSTRATPSRRT 440
            |.|:.|......||
  Rat   450 SSRDVTSTNRQIRT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	109/370 (29%)
		Ax_dynein_light	<283..377	CDD:287215	26/104 (25%)
		LTD	466..572	CDD:279300
Krt14	NP_001008751.1	Head. /evidence=ECO:0000250\|UniProtKB:P02533	1..121		119/404 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Filament	121..432	CDD:278467	109/371 (29%)
		Coil 1A. /evidence=ECO:0000250\|UniProtKB:P02533	122..157		22/37 (59%)
		Linker 1. /evidence=ECO:0000250\|UniProtKB:P02533	158..175		5/42 (12%)
		Coil 1B. /evidence=ECO:0000250\|UniProtKB:P02533	176..267		26/104 (25%)
		Linker 12. /evidence=ECO:0000250\|UniProtKB:P02533	268..290		6/28 (21%)
		Coil 2. /evidence=ECO:0000250\|UniProtKB:P02533	291..429		47/148 (32%)
		Tail. /evidence=ECO:0000250\|UniProtKB:P02533	430..485		10/34 (29%)
		Interaction with Type I keratins and keratin filaments. /evidence=ECO:0000250	432..485		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..458		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000