DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and Nefm

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_058725.1	Gene:	Nefm / 24588	RGDID:	3160	Length:	845	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	113/449 - (25%)
Similarity:	212/449 - (47%)	Gaps:	62/449 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRL 114
            ||..||.:||.||||.|.||::|..||.:|..:..|:...|...... ..:.:.::.|:.|.|..
  Rat    95 SRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIHALRQKQASH-AQLGDAYDQEIRELRAT 158

  Fly   115 LDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRK 179
            |:....::|:.::|...|.|:...||.:.:::.
  Rat   159 LEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEA-------------------------------- 191

  Fly   180 KLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRI 244
            :|.:|...|::.|          ||::|:.::.:|:|:..:|||::|::|....|.:|:.:  .:
  Rat   192 RLRDDTEAAIRAL----------RKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVAD--LL 244

  Fly   245 KQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTH 309
            .|.:.|.|...........:..:|:|:|:|.|.....|..:.:..::.:..:|.|||.:...:..
  Rat   245 AQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIR 309

  Fly   310 KSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREE 374
            .:.||:...|.::.:.:..:..:......|..::.|:|.:.::|...:...|..||.||...:.|
  Rat   310 SAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWE 374

  Fly   375 MTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ-SLRNSTRATPSR 438
            |.:.|:|||||:::|::||:|||||.|||.|||.|.:....:.|..:.:..| |:..|::...::
  Rat   375 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTK 439

  Fly   439 -RTPSAAVKRK--RAVVDES--EDH--------SVADYYVSASA---KGNVEIKEIDPE 481
             ..|...|:.|  ..:::|:  ||.        :|....::|||   |...|.||.:||
  Rat   440 VEAPKLKVQHKFVEEIIEETKVEDEKSEMEDALTVIAEELAASAKEEKEEAEEKEEEPE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	90/354 (25%)
		Ax_dynein_light	<283..377	CDD:287215	18/93 (19%)
		LTD	466..572	CDD:279300	9/19 (47%)
Nefm	NP_058725.1	Filament_head	10..97	CDD:282575	1/1 (100%)
		Filament	98..409	CDD:278467	90/355 (25%)
		Coil 1A	103..134		14/30 (47%)
		Linker 1	135..147		1/12 (8%)
		Coil 1B	148..246		26/141 (18%)
		Linker 12	247..263		2/15 (13%)
		Coil 2A	264..285		6/20 (30%)
		Linker 2	286..289		0/2 (0%)
		Coil 2B	290..410		38/119 (32%)
		Tail	411..844		20/88 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..782		8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910