DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Gfap

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_058705.2	Gene:	Gfap / 24387	RGDID:	2679	Length:	430	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	143/505 - (28%)
Similarity:	228/505 - (45%)	Gaps:	112/505 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKSRRAGTATPQPGNTST------PRPPSAGPQPPPPSTHSQTASSPLSP-TRHSRVAEKVELQ 59
            |::...|.:.|...|:..|      ||...:...||.|:....:.:..|:. .:.:|.:|:.|:.
  Rat     8 SARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMM 72

  Fly    60 NLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRAR 124
            .||||.|:||::||.||.:|..|..|:...|   .:|.|.:.::::|||.|.|..||....:.||
  Rat    73 ELNDRFASYIEKVRFLEQQNKALAAELNQLR---AKEPTKLADVYQAELRELRLRLDQLTTNSAR 134

  Fly   125 AEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEAL 189
            .|::...|.::...|:.||..:|.....||.|:.:|...|:|
  Rat   135 LEVERDNLTQDLGTLRQKLQDETNLRLEAENNLAVYRQEADE----------------------- 176

  Fly   190 KELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINE--SRRIKQTEYSEI 252
                               .||:|||||..::||.||:.|..:||.:|:.|  .:..:|..:.|:
  Rat   177 -------------------ATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLAQQQVHVEM 222

  Fly   253 DGRLSSEYDAK--LKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEEL 315
            |       .||  |..:|:|:|.|||.....|..|.:..|..|...|.:.|:|.:....::..|.
  Rat   223 D-------VAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAELLRQAKHEA 280

  Fly   316 RSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQE-------IDLLEKELIRLRE 373
            ...|.::.||..::..|...|       ..||||:....|||.:|       :..||:|...|:|
  Rat   281 NDYRRQLQALTCDLESLRGTN-------ESLERQMREQEERHARESASYQEALARLEEEGQSLKE 338

  Fly   374 EMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ-SLRNSTRATPS 437
            ||.:.|:|||||:::|::||:|||.|.|||.|||.|:       |..||:||. .:|.::..|.|
  Rat   339 EMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRI-------TIPVQTFSNLQIRETSLDTKS 396

  Fly   438 RRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEID-PEGKFVR 486
                            .||.|          .|.|:.:|.:: .:|:.::
  Rat   397 ----------------VSEGH----------LKRNIVVKTVEMRDGEVIK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	115/365 (32%)
		Ax_dynein_light	<283..377	CDD:287215	27/100 (27%)
		LTD	466..572	CDD:279300	4/22 (18%)
Gfap	NP_058705.2	Head	1..70		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		5/22 (23%)
		Filament_head	4..64	CDD:282575	11/55 (20%)
		Filament	66..374	CDD:278467	115/366 (31%)
		Coil 1A	71..102		14/30 (47%)
		Linker 1	103..113		3/12 (25%)
		Coil 1B	114..212		37/139 (27%)
		Linker 12	213..228		5/21 (24%)
		Coil 2A	229..250		8/20 (40%)
		Linker 2	251..254		0/2 (0%)
		Coil 2B	255..375		45/126 (36%)
		Tail	376..430		15/71 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910