DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Krt90

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_808385.2	Gene:	Krt90 / 239673	MGIID:	3045312	Length:	538	Species:	Mus musculus

Alignment Length:	423	Identity:	115/423 - (27%)
Similarity:	199/423 - (47%)	Gaps:	86/423 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GPQPPPPSTHSQTASSPLSPTRH---------SRVAEKVELQNLNDRLATYIDRVRNLETENS-- 80
            |..|.....|..|.:..|....|         .|..||.:::.||::.|::||:||.||.:|.
Mouse   107 GMAPGAGGIHEVTVNQSLLTPLHLEIDPSLQRVRKEEKEQIKTLNNKFASFIDKVRFLEQQNKVL 171

  Fly    81 ----RLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKN 141
                .|..|.:|||       ||::.:|||.:...||.|:....:|:|.|.::|.:.:..|:.||
Mouse   172 ETKWSLLQEHKTTR-------TNLEPMFEAYITNLRRQLECLGGERSRLETELKSMQDVVEDFKN 229

  Fly   142 KLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNL 206
            |.:::....|.||                                          .:|...:|::
Mouse   230 KYEEEIHRRTAAE------------------------------------------NEFVVLKKDV 252

  Fly   207 EQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLK--QSLQ 269
            :...:::|:||..:::|.:|::|.......|:.:    .|.:.||....||.:.:..|.  ..:.
Mouse   253 DAAYMNKVELEAKVEALMDEINFLRAFFEAELAQ----LQAQISETSVVLSMDNNRSLNLDSIIA 313

  Fly   270 ELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALN-------A 327
            |::||||:....:|.|.:|.|:.|.:.||.:|.:..       ::||:|::.|..||       :
Mouse   314 EVKAQYEDIANRSRAEAESWYQTKYEELQRSAGQRG-------DDLRTTKMEISELNRAMQRLRS 371

  Fly   328 NINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSL 392
            .|:.|::..|.|.|.|.|.|::.:...:....::..||..|.:.:::|.:||:|||:||::|::|
Mouse   372 EIDNLKKQCATLQASIADAEQRGELALKDAKNKLAELEDALQKAKQDMARQLREYQELMNVKLAL 436

  Fly   393 DLEIAAYDKLLVGEEARL--NITPATNTATVQS 423
            |:|||.|.|||.|||.||  ....|.|.:.|.|
Mouse   437 DIEIATYRKLLEGEECRLTGEGVGAVNISVVSS 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	102/369 (28%)
		Ax_dynein_light	<283..377	CDD:287215	26/100 (26%)
		LTD	466..572	CDD:279300
Krt90	NP_808385.2	Keratin_2_head	16..139	CDD:292825	6/31 (19%)
		Filament	142..453	CDD:278467	102/370 (28%)
		GluZincin	214..>291	CDD:301352	19/122 (16%)
		DUF883	366..>426	CDD:295076	14/59 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910