DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Krt79

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_666175.1	Gene:	Krt79 / 223917	MGIID:	2385030	Length:	531	Species:	Mus musculus

Alignment Length:	412	Identity:	109/412 - (26%)
Similarity:	194/412 - (47%)	Gaps:	87/412 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GPQPPPPS----THSQTASSPLS-----PTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRL 82
            ||..||..    |.:|:..:||:     ..:..|..|:.:::.||::.|::||:||.||.:|..|
Mouse   103 GPVCPPGGIQEVTVNQSLLTPLNVEIDPEIQRVRTQEREQIKTLNNKFASFIDKVRFLEQQNKVL 167

  Fly    83 -----TIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNK 142
                 .::.|:....|.|   :::..||..|...||.||....:|.|.:::::.:.:..|:.|||
Mouse   168 ETKWALLQEQSQNTGVAR---SLEPFFENYLSTLRRQLDTKQSERGRLDMELRNVQDNLEDFKNK 229

  Fly   143 LDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLE 207
                             ||   :|:|.:                      ..|..:|...:|:::
Mouse   230 -----------------YE---DEINKR----------------------TALENEFVLLKKDVD 252

  Fly   208 QETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAK--LKQSLQE 270
            ...:.|:||...:.||.:|:.|..|:...|:::    .||..|:.:..||.:.:..  |...:.|
Mouse   253 AAYMGRMDLHGKVDSLTQEIDFLQQLFEMELSQ----VQTNVSDTNVILSMDNNRNLDLDSIIAE 313

  Fly   271 LRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNS---THKSIEELRSTRVR----IDALNAN 328
            ::||||...|.:|.|.:|.|:.|.:.||..|.:..:|   |...|.||..|..|    :||....
Mouse   314 VKAQYELIAQKSRAEAESWYQTKYEELQVTAGKHGDSLRDTKNEIAELTRTTQRLQGEVDAAKKQ 378

  Fly   329 INELEQANADLNAR----IRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIK 389
            ..:|:.|.|:....    ::|.:::|.:           |:..|.:.:|::.:.|:|||||:.:|
Mouse   379 CQQLQTAIAEAEQNGEMALKDAKKKLGD-----------LDTALHQAKEDLARMLREYQDLVSVK 432

  Fly   390 VSLDLEIAAYDKLLVGEEARLN 411
            ::||:|||.|.|||..||:|::
Mouse   433 LALDMEIATYRKLLESEESRMS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	99/372 (27%)
		Ax_dynein_light	<283..377	CDD:287215	25/104 (24%)
		LTD	466..572	CDD:279300
Krt79	NP_666175.1	Head	1..138		9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Keratin_2_head	<62..135	CDD:292825	8/31 (26%)
		Filament	138..452	CDD:278467	99/373 (27%)
		Coil 1A	139..174		12/34 (35%)
		Linker 1	175..194		5/21 (24%)
		Coil 1B	195..286		27/136 (20%)
		Linker 12	287..310		6/22 (27%)
		Coil 2	311..449		47/148 (32%)
		Tail	450..531		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910