Protein Alignment Lam and Krt73

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_997650.1
• Gene: Krt73 / 223915
• MGIID: 3607712
• Length: 539
• Species: Mus musculus
• Alignment Length: 520
• Identity: 129/520 - (24%)
• Similarity: 231/520 - (44%)
• Gaps: 92/520 - (17%)

  Fly     4 KSRRAGTATPQPGNTSTPRPPSAGPQPP----PPSTHSQTAS-SPLSP--------TRHSRVAEK 55
            ::|.:|.|....|:      .:.||..|    |...|..|.: |.|:|        .:..|..|:
Mouse    74 RNRASGFAGSMFGS------GALGPSNPSLCLPGGIHQVTVNKSLLAPLNVELDPEIQKVRAQER 132

  Fly    56 VELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRD-TVTRETTNIKNIFEAELLETRRLLDDTA 119
            .:::.||::.|::||:||.||.:|..|..:.:..:. .::....|::.::||.:...::.||..:
Mouse   133 EQIKALNNKFASFIDKVRFLEQQNQVLQTKWELLQQLDLSNCRRNLEPVYEAHISSLQKQLDSLS 197

  Fly   120 RDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNED 184
            .||.|.:.:::.:.:..|:.|.:.:::..:.||||
Mouse   198 GDRVRLDSELRGMRDAVEDCKKRYEEEINKRTTAE------------------------------ 232

  Fly   185 LNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEY 249
                        .:|...:|:::...:|:|:|:..:.:|..|:.|...::..||.:    .|:..
Mouse   233 ------------NEFVVLKKDVDAAYMSKVELQAKVDALDGEIKFLKCLYEGEITQ----MQSHI 281

  Fly   250 SEIDGRLSSEYDAK--LKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNS---TH 309
            |:....||.:.:..  |...:.|:|||||:....::.|.:.:|:.|.|.||.||.|..:.   |.
Mouse   282 SDTSVVLSMDNNRNLDLDSIIAEVRAQYEDIALKSKAEAEMVYQTKFQELQLAAGRHGDDLKHTR 346

  Fly   310 KSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREE 374
            ..|.||  ||: |..|.:.|..:::..::|...|.|.|::.|...:....::|.||:.|.:.:||
Mouse   347 NEISEL--TRL-IQRLRSEIESVKKQCSNLETAIADAEQRGDCALKDARAKLDELERALHQAKEE 408

  Fly   375 MTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRR 439
            :.:.|:|:|:||.:|::||:|||.|.|||.|||.|:: ...|:..::...|.|...:..|..|..
Mouse   409 LARMLREHQELMSMKLALDIEIATYRKLLEGEECRMS-GEHTSAVSISVISSSAPGTVGAGTSFG 472

  Fly   440 TPSAAVKRKRAVVDESEDHSVADYYVSAS-----AKGNVEIKEIDPEGKFVRLFNKGSEEVAIGG 499
            ..||.....|       ..|||..|...|     ..||     ..|.|.........||...:.|
Mouse   473 FSSAGTYGYR-------QSSVAGGYGILSGGCVTGSGN-----CSPRGDTKNRLGSASEFKEVSG 525

  Fly   500  499
            Mouse   526  525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	94/360 (26%)
		LTD	467..572	CDD:460003	8/38 (21%)
Krt73	NP_997650.1	Head	1..130		14/61 (23%)
		Keratin_2_head	15..127	CDD:465068	13/58 (22%)
		Filament	130..443	CDD:459643	94/361 (26%)
		Coil 1A	131..166		12/34 (35%)
		Linker 1	167..185		2/17 (12%)
		Coil 1B	186..277		21/136 (15%)
		Linker 12	278..301		5/22 (23%)
		Coil 2	302..440		50/140 (36%)
		Tail	441..539		22/98 (22%)