DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and lmnl3

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_694505.2	Gene:	lmnl3 / 195817	ZFINID:	ZDB-GENE-020424-4	Length:	584	Species:	Danio rerio

Alignment Length:	612	Identity:	182/612 - (29%)
Similarity:	324/612 - (52%)	Gaps:	39/612 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TSTP--RPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENS 80
            ||||  |..||..:   .|..|..:...:||||.:|:.||.:|:.||||||.||:|||.||.:.|
Zfish     5 TSTPMERSASAAVR---ASRRSGASPCTVSPTRLTRLQEKEDLRQLNDRLANYIERVRQLEADKS 66

  Fly    81 RLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDK 145
            .:.|.::...::..||..|::.::|:||.:.|:.||.||.:|||.:|:..:|.|::.:|..:.:|
Zfish    67 SMQILLEEKEESSLREVGNVRRLYESELADARKSLDATANERARLQIEFSQLQEDHRKLAARNNK 131

  Fly   146 KTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQET 210
            |..|.|.|....|..|...|.....:....:..::|..:::|...::..|....::.:..|..|.
Zfish   132 KECELTAAVDRWRNLEVALNAKEADFANLLSTNRRLETEISELKTQVPALEAALQKLKTQLNSEM 196

  Fly   211 LSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQY 275
            |.|||.||.||:|:|:|.|:..:..||:.|.|...::...|:|.....|::.||.:::::||.::
Zfish   197 LRRVDAENQIQTLQEQLDFQKHLGEQEVREMRSRHESRLLELDCGRQKEFEGKLAEAMKQLRDEH 261

  Fly   276 EEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLN 340
            |.|::..:||::..:..|::..::.|.:.|:....:.|||..|::|:::....||.|::....|.
Zfish   262 ETQIRQYKDELEKTFNAKLENAKQTAVKNSDFAFSTKEELAGTKLRLESQTQQINNLQKQVVCLE 326

  Fly   341 ARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVG 405
            ||:.:|::.|:::|:...|::...::|:..||.:|.:||:||::|:|:|:.||:||.||.|:|.|
Zfish   327 ARVLELQQTLEHERQVSQQKLSQQQQEMAALRLQMQEQLEEYENLLDVKLMLDMEINAYRKMLEG 391

  Fly   406 EEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVK--RKRAVVDESEDHSVADYYVS-- 466
            ||.|||              |||      :|.::|.|..::  ||:...|.:......:|.:|
Zfish   392 EEKRLN--------------QSL------SPIQQTLSPIIQQSRKKRKHDATCSGFSPNYRLSQH 436

  Fly   467 ASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITV 531
            :|.:|.|.|:|:|.:|::::|.|....:..:.|||| |....:.|...:.|.....:....::||
Zfish   437 SSCRGPVSIEEVDLDGRYIKLKNASDRDQVVSGWQL-RKSEAEAPDIVFCFPSPCVMNAGHMLTV 500

  Fly   532 WSADTKASHEPPSSLVMKS-QKWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRS 595
            |:|.........|.|::.: |.|.|..:.|..|||.:.|.:|....::....:...|....|.|
Zfish   501 WAAAAVDQCGSASDLLLSTHQSWGSFADVRVSLLNIQNEEMAEYYVVQDKTEEDAESDEPVRSR- 564

  Fly   596 VTAVDGNEQLYHQQGDPQQSNEKCAIM 622
                   :....:||.....:..|.:|
Zfish   565 -------DAHMRRQGQTLDHDSACLLM 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	116/354 (33%)
		Ax_dynein_light	<283..377	CDD:287215	24/93 (26%)
		LTD	466..572	CDD:279300	31/108 (29%)
lmnl3	NP_694505.2	Filament	39..395	CDD:278467	116/355 (33%)
lmnl3	NP_694505.2	LTD	436..544	CDD:279300	31/108 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1815
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm6402
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.890