DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and lmnb1

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_694504.2	Gene:	lmnb1 / 195816	ZFINID:	ZDB-GENE-020424-2	Length:	588	Species:	Danio rerio

Alignment Length:	605	Identity:	220/605 - (36%)
Similarity:	345/605 - (57%)	Gaps:	25/605 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTI 84
            ||    ||.|    |....|:|:||||.|.||:.||.|||.||||||.|||.||:||:|||.|.|
Zfish     7 TP----AGQQ----SLSRGTSSTPLSPARISRLQEKEELQQLNDRLAAYIDTVRSLESENSVLQI 63

  Fly    85 EVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKE 149
            :::...|...||.|.::.::|.||.:.|:.||||||:|||.:|::.::..|.|:|::...||..:
Zfish    64 QIREREDVRNRELTGLRTLYETELADARKALDDTARERARLQIELGKIKSEQEQLQHTYAKKDAD 128

  Fly   150 CTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRV 214
            .|:::..::..|:..|......|.|.::||.|...|::....::.|.......:|.|..|||.||
Zfish   129 LTSSQNRLKDVEALLNAKEAALNTAVSERKTLENTLSDLQIRVQELEGGLISAKKQLSDETLLRV 193

  Fly   215 DLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQM 279
            ||||..|||.|||.|:..:..:||.::||..:|...|:|.....||:.||.|:|.::|.|::||:
Zfish   194 DLENRCQSLMEELEFRKNMFEEEIKDTRRRHETRLVEVDSGRQMEYEFKLAQALTDMRQQHDEQV 258

  Fly   280 QINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIR 344
            ::.::|::..|..|::.::.::...|:|...:.||||.:.:|:::|...:..|::.......||.
Zfish   259 KLYKEEMEQTYVSKLENIRLSSEMNSSSASMAREELRESTLRVESLAGQLANLQKEARAWQDRIN 323

  Fly   345 DLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEAR 409
            :||..|.::::...:.:...|:|:..:|.:|.|||.||:.|:|:|::||:||.||.|||.|||.|
Zfish   324 ELEGALSHEKDLSRRLLAEKEREIAEIRAKMQQQLDEYEQLLDVKLALDMEINAYRKLLEGEEER 388

  Fly   410 LNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVE 474
            |.::|:.::....|         ||:.||...:...||||..|:|||..|......||||.|||.
Zfish   389 LKLSPSPSSRVTVS---------RASSSRSVRTTRGKRKRVDVEESEASSSVSIAHSASATGNVS 444

  Fly   475 IKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKAS 539
            |.|:|.:|||:||.|...::..:.|:||.|.|.|  .:.||||.....::....:|:|:::...|
Zfish   445 IDELDVDGKFIRLHNNSEQDQPMAGFQLTRTIGE--VTATYKFTAKYNLKAGQKVTIWASNAGIS 507

  Fly   540 HEPPSSLVMKSQ-KWVSADNTRTILLNSEGEAVANLDRI-KRIVSQHTSSSRLSRRRSVTAVDGN 602
            ..||:.|:.|:| .|.:.:|.:..||:..||.||....: |..|..........:...|.    .
Zfish   508 SNPPADLIWKNQPSWGTGENIKVALLSPAGEKVAVRSTVFKTAVEDEDDDEEEEKEAEVI----E 568

  Fly   603 EQLYHQQGDPQQSNEKCAIM 622
            |:.|||||||:.:...|.||
Zfish   569 ERFYHQQGDPRAAKRGCLIM 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	132/354 (37%)
		Ax_dynein_light	<283..377	CDD:287215	21/93 (23%)
		LTD	466..572	CDD:279300	40/106 (38%)
lmnb1	NP_694504.2	Filament	32..388	CDD:278467	132/355 (37%)
lmnb1	NP_694504.2	LTD	436..544	CDD:279300	42/109 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1815
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1927
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm6402
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	LDO	PTHR45721
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980