Protein Alignment Lam and lmna

DIOPT Version :9

• Sequence 1: NP_001245892.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_694503.1
• Gene: lmna / 195815
• ZFINID: ZDB-GENE-020424-3
• Length: 659
• Species: Danio rerio
• Alignment Length: 599
• Identity: 215/599 - (35%)
• Similarity: 349/599 - (58%)
• Gaps: 32/599 - (5%)

  Fly    44 LSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAEL 108
            |||||.||:.||.:|.|||||||.|||:||:||.||:.|.:.:..:...::||.:.:|..:||||
Zfish    18 LSPTRISRLQEKEDLSNLNDRLAVYIDKVRSLEVENAGLRMRITESETEISRELSGMKAAYEAEL 82

  Fly   109 LETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQ 173
            .:.|:.||..|::|||.::::.::.|:.:|||.:..||..:..:|...::..||..|..:...:.
Zfish    83 ADARKTLDSVAKERARLQLELSKVREDYKELKARNGKKEADLESALARLKDLESLLNSKDASLST 147

  Fly   174 ANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEI 238
            |..:::.|..::.:...:|.:|.....:.:|.|:.|.|.|||.||.||:|:|||.|:..|:|:|:
Zfish   148 ALGEKRTLEVEVRDLKAQLAKLEGSLNDAKKQLQDEMLRRVDAENRIQTLKEELEFQKNIYSEEL 212

  Fly   239 NESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAAR 303
            .||:|..::...|||.....:|::||..:|.:||.|:|||::|.::||:..|..|::..:.:|.|
Zfish   213 RESKRRYESRVVEIDSGRQQDYESKLADALTDLRNQHEEQLRIYKEEIEKTYNSKLENARSSAER 277

  Fly   304 TSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKEL 368
            .|:....:.|||:.||||::.:::.:::|::..|...|:||:||..|..:|:...:.::..|||:
Zfish   278 NSHLVGAAHEELQQTRVRMEGVSSQLSQLQKQLAAREAKIRELEEALSRERDILRRRLEDKEKEM 342

  Fly   369 IRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTA---TVQSFSQSLRN 430
            ..:|:.|.|||.|||:|:|||::||:||:||.|||.|||.||.::|:...|   ||...|.| .:
Zfish   343 AEMRQRMQQQLDEYQELLDIKLALDMEISAYRKLLEGEEERLRLSPSPPPARGVTVTRSSGS-GS 406

  Fly   431 STRATPS--RRTPSAAVKRKRAVVDESEDHSVAD-------YYVSASAKGNVEIKEIDPEGKFVR 486
            .||...|  .||.|.:.|::|...::|:..||..       .:..|||.|.|.:.|:|.||||||
Zfish   407 HTRVVQSSTSRTSSGSAKKRRLNDNDSDASSVVGGTVTRTRIFQQASASGRVTVDEVDLEGKFVR 471

  Fly   487 LFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQ 551
            |.||..::.::|.||::|.|. .|....|||.....::....:|:|:|....:|.|||.||.|:|
Zfish   472 LNNKSDQDQSLGHWQVKRQIG-SGTPIVYKFPPKFNLKAGQTVTIWAAGAGGTHSPPSDLVWKTQ 535

  Fly   552 -KWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRR----------RSVTAVDGNEQL 605
             .|.|.|..:|.|::|.||.:| :.::.|.:.|......::..          ||.|.:.|:
Zfish   536 NSWGSGDLFQTTLISSSGEEMA-MRKVTRTLFQDEEDDEMAAHSTCGDSEYNLRSRTVLCGS--- 596

  Fly   606 YHQQGDPQQSNEKC 619
               .|.|...|..|
Zfish   597 ---CGQPSDRNSSC 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	134/354 (38%)
		Ax_dynein_light	<283..377	CDD:287215	28/93 (30%)
		LTD	466..572	CDD:279300	44/106 (42%)
lmna	NP_694503.1	Filament	27..383	CDD:278467	134/355 (38%)
		Uso1_p115_C	102..202	CDD:282695	28/99 (28%)
		BAR	<237..>350	CDD:299863	37/112 (33%)
		DUF972	295..>359	CDD:283750	21/63 (33%)
		Exonuc_VII_L	<322..400	CDD:280721	35/77 (45%)
		LTD	451..559	CDD:279300	45/109 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1815
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1927
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm6402
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	LDO	PTHR45721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2618
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870