DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lam and Nefl

DIOPT Version :9

Sequence 1:NP_001245892.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_035040.1 Gene:Nefl / 18039 MGIID:97313 Length:543 Species:Mus musculus


Alignment Length:517 Identity:138/517 - (26%)
Similarity:237/517 - (45%) Gaps:85/517 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSKSRRAGTATPQPGNTSTPRPPSAGPQPPPPSTH----SQTASSPLSPTRHSRVAEKVELQNLN 62
            :::|..:..:.|...:.|..|..|:......||..    ||.|:.. :..:..|..||.:||:||
Mouse    35 TARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAIS-NDLKSIRTQEKAQLQDLN 98

  Fly    63 DRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEI 127
            ||.|::|:||..||.:|                      .:.|||||..|:...:.:|.||..|.
Mouse    99 DRFASFIERVHELEQQN----------------------KVLEAELLVLRQKHSEPSRFRALYEQ 141

  Fly   128 DIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKEL 192
            :|:       :|:...:..|.|....:|.....|.....|..:|.:....|:.....|.||    
Mouse   142 EIR-------DLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEA---- 195

  Fly   193 ERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLS 257
                      ||..::..|:|.:||..|.||.:|::|..::|.:||.|.:  .|.:|::|...:.
Mouse   196 ----------RKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQ--AQIQYAQISVEMD 248

  Fly   258 SEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRI 322
            ......|..:|:::|||||:....|....:..::.:...|.|:||:.:::...:.:|:..:|..:
Mouse   249 VSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLL 313

  Fly   323 DALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMD 387
            .|....|......|..|..::::||.:.:.|.......|:.||.||...:.||.:.|||||||::
Mouse   314 KAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRSTKSEMARYLKEYQDLLN 378

  Fly   388 IKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQS-----------LRNSTRATPSRRTP 441
            :|::||:|||||.|||.|||.||:.|...:..:  .:|||           |::|:....:|..|
Mouse   379 VKMALDIEIAAYRKLLEGEETRLSFTSVGSITS--GYSQSSQVFGRSAYSGLQSSSYLMSARSFP 441

  Fly   442 ---SAAVKRKRAVVDESEDHSVADYYVSASAK------GNVEIKEIDPEGKFVRLFNKGSEE 494
               ::.|:.::..|:|:.:.:.|:     .||      |..|.:|.:.|        :|.||
Mouse   442 AYYTSHVQEEQTEVEETIEATKAE-----EAKDEPPSEGEAEEEEKEKE--------EGEEE 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_001245892.1 Filament 54..409 CDD:278467 104/354 (29%)
Ax_dynein_light <283..377 CDD:287215 20/93 (22%)
LTD 466..572 CDD:279300 9/35 (26%)
NeflNP_035040.1 Head 2..93 13/58 (22%)
Filament_head 9..88 CDD:309741 10/53 (19%)
Filament 89..400 CDD:306535 104/355 (29%)
Coil 1A 94..125 18/52 (35%)
Linker 1 126..138 3/11 (27%)
Coil 1B 139..234 27/115 (23%)
Linker 12 235..253 3/19 (16%)
Coil 2A 254..272 7/17 (41%)
Linker 2 273..281 1/7 (14%)
Coil 2B 282..397 38/114 (33%)
Epitope, recognized by IF-specific monoclonal antibody 382..392 7/9 (78%)
Tail 398..543 24/108 (22%)
Tail, subdomain A 398..444 11/47 (23%)
Tail, subdomain B (acidic) 445..543 13/59 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..543 12/55 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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