DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and ifc-1

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_503783.1	Gene:	ifc-1 / 178747	WormBaseID:	WBGene00002055	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	97/414 - (23%)
Similarity:	177/414 - (42%)	Gaps:	58/414 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAEL---- 108
            |.:|..||.|:..||||||.||::||.|:.:|..|:.:::..|...: ...:|.:.||:|:
Worm    27 RDAREREKREIGLLNDRLADYIEKVRFLKAQNHVLSHDIEILRRGFS-GGGHISSFFESEISNCT 90

  Fly   109 LETRRLLDDTARDRA-----RAEIDI-KRLWEE--------NEELKNKLDKKTKECTTAEGNVRM 159
            :.:.|:|....:.:|     ..||:| ::.|.|        .|:....|||..:    .|..:.:
Worm    91 VISERILSSRTKFQADITGLEGEIEIYRKKWLEALKVVRSHREDHHVNLDKLAE----VEAQIAL 151

  Fly   160 YESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQ------FEETRKNLEQETLSRVDLEN 218
            :       |.|......|..::..:......::.|:..|      .:..|.:..|..|.||.:..
Worm   152 F-------NRKIRIVEEDVLRIRRETGGIQNDIGRIHSQIHAEIALKNERHHSVQMLLQRVQVIQ 209

  Fly   219 TIQSLR--EELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQI 281
            |..|.|  :||.:   ||.....|:|     :|          :..:|:.:::::||.||.....
Worm   210 TENSSRIEQELIY---IHRDTTLENR-----DY----------FRQELQAAMRDIRANYEAMSIR 256

  Fly   282 NRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDL 346
            :|::|:..|..:|..::...|......::  |||.|.|..:...::.:.|:|..||.|...|.||
Worm   257 SREDIEIAYRKRIDEIRVIPAHVHIEDYR--EELLSIRTTLSTTHSRLAEIESRNAWLLTTITDL 319

  Fly   347 ERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLN 411
            :.|...:.......:|..:....:.:|..|:...:.:.|.|.:.||..|:..|..||.|......
Worm   320 KHQQAEEARIFEATLDAKQATYEQFKERCTELSIQMEKLCDHETSLQAELERYRVLLNGANVTTY 384

  Fly   412 ITPATNTATVQSFSQSLRNSTRAT 435
            ::.:|..|..:|.:.....:|..|
Worm   385 VSNSTGAAGYRSSTHVATTTTTTT 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	90/380 (24%)
		Ax_dynein_light	<283..377	CDD:287215	21/93 (23%)
		LTD	466..572	CDD:279300
ifc-1	NP_503783.1	Filament	33..378	CDD:278467	89/376 (24%)
		DUF1517	382..>484	CDD:295038	5/27 (19%)
		Loricrin	<386..487	CDD:292475	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7818
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820