DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and ifb-2

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001293525.1	Gene:	ifb-2 / 173973	WormBaseID:	WBGene00002054	Length:	577	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	144/573 - (25%)
Similarity:	260/573 - (45%)	Gaps:	55/573 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 STHSQTASSPLSPTRHSRVA--------------EKVELQNLNDRLATYIDRVRNLETENSRLTI 84
            |.|..|.::  |.:.|..|:              ||.|:|.||.||..||.|||.||..|..|.|
Worm     7 SMHRTTTTT--SSSSHGGVSAGHAAEEFVASAEREKQEMQQLNSRLEVYISRVRQLEDRNKELVI 69

  Fly    85 EVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKE 149
            |:.|.|.::..:...||..|...|::.||.:.:........|:.:.||.::..:.:::.::..:|
Worm    70 ELDTLRGSLGNDIGQIKFKFNDSLVKVRREISEAHSGTIGVEVKVDRLRDDLNDYRHRYEEARRE 134

  Fly   150 C----TTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQET 210
            .    ||..|.:...::..:...::|.....:.|:|       ..|.::|..|....:..|:...
Worm   135 VEREKTTWGGAISQAQAELDTNKSRYAAILDEEKRL-------YAEQDQLYLQLAAAKDELDAAI 192

  Fly   211 LSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQY 275
            :.|..|:.....|:.||.|..:||||||.|.|    |..::........:..:|..:::|::|:|
Worm   193 VDRRRLQAEEDDLKIELEFLGRIHSQEITELR----TLLAQAPADTREFFKNELALAIREIKAEY 253

  Fly   276 EEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLN 340
            ::.:|..|.:::::::.||..::.:....:.:.....||:|.....|..|.|.::|||..|:.|.
Worm   254 DKIIQTTRVDLETIFQSKISAVESSIVSKNEAAVFRQEEIRKMNESITTLRAKLSELEARNSALE 318

  Fly   341 ARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVG 405
            .....|:.||..|:..:..|:...:..|..:||:....:.|.|.|::.|.:||.|||.|.||:..
Worm   319 REANTLQIQLGEDQRAYESELHKRDNALRFMREDCQTLIAELQALLNTKQTLDTEIAIYRKLVES 383

  Fly   406 EEARLNITPATNTATVQSFSQSLRNSTRATP-------------SRRTPSAAVKRKRAVVDESED 457
            ||.|..   ......|.:..::.|....:||             .::.|....:....:|...:|
Worm   384 EEGRFT---HVGQGVVVAQQETTRTEGDSTPVVLNDQQYSDSHQYQQYPEVYPQGTLRLVPVEQD 445

  Fly   458 HSVADYYVSAS-----AKGNVEIKEIDPEGKFVRLFN-KGSEEVAIGGWQLQRLINEKGPSTTYK 516
            |..:....:.|     |||||.|.|.||:||::.|.| .||....:..::::|:| :...:..::
Worm   446 HWDSGEVQTRSSFKRHAKGNVSIVECDPQGKYIILENTSGSVAEDVSNFEIRRVI-DGVQAFVFR 509

  Fly   517 FHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQ-KWVSADNTRTILLNSEG 568
            ....:.|:.:|.:.::..::...:.||.|:||:|. .|.......|.|.||.|
Worm   510 LPSHLVIQQHGHLKIYGRNSGGINSPPDSIVMESHPSWGQGGQVETFLYNSHG 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	97/358 (27%)
		Ax_dynein_light	<283..377	CDD:287215	22/93 (24%)
		LTD	466..572	CDD:279300	32/110 (29%)
ifb-2	NP_001293525.1	Filament	39..387	CDD:278467	97/358 (27%)
		ATP-synt_B	153..307	CDD:304375	36/164 (22%)
		LTD	462..568	CDD:279300	31/102 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I1825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7818
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920