Protein Alignment Lam and lmn-1

DIOPT Version :9

• Sequence 1: NP_001245892.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_492371.1
• Gene: lmn-1 / 172687
• WormBaseID: WBGene00003052
• Length: 566
• Species: Caenorhabditis elegans
• Alignment Length: 611
• Identity: 183/611 - (29%)
• Similarity: 296/611 - (48%)
• Gaps: 81/611 - (13%)

  Fly    35 THSQTASSPLSPT------------RHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQ 87
            |..::|:|.||..            ..||:.||..|.:||.|||||||:||.||.||:||.::::
 Worm    14 TLERSANSSLSNNGGGDDSFGSTLLETSRLQEKDHLTSLNSRLATYIDKVRQLEQENNRLQVQIR 78

  Fly    88 TTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTT 152
            .......:|.:|:.:.||||....||.||....:.|:..|:......|.::||.:::|..:|...
 Worm    79 DIEVVEKKEKSNLADRFEAEKARLRRALDSAQDELAKYRIEYDAAKVEVKKLKPQVEKLERELAG 143

  Fly   153 AEGNVRMYESRANELNNKYNQANADRKKL---NEDLNEALKELERLRKQFEETRKNLEQETLSRV 214
            ||......:|.|::...|.....|...||   |:||.   |:...||...|..:|.:|.|||.|.
 Worm   144 AEEQALHAQSIADQSQAKQKTLQARNDKLVVENDDLK---KQNITLRDTVEGLKKAVEDETLLRT 205

  Fly   215 DLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQM 279
            ...|.|::|.|:|:|..|.|..|:.|.|..:|.:.:....:::.||.:||:..::|:|||::..:
 Worm   206 AANNKIKALEEDLAFALQQHKGELEEVRHKRQVDMTTYAKQINDEYQSKLQDQIEEMRAQFKNNL 270

  Fly   280 QINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIR 344
            ..|:...:..|::|:           |:..:..||..|..:.   |.|.:.:||.:::...:.|.
 Worm   271 HQNKTAFEDAYKNKL-----------NAARERQEEAVSEAIH---LRARVRDLETSSSGNASLIE 321

  Fly   345 DLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEAR 409
            .|..:||..:....:::|..:..:..|.:|:.:.:.|:.||:|:|:.||.|:..|..||.|||.|
 Worm   322 RLRSELDTLKRSFQEKLDDKDARIAELNQEIERMMSEFHDLLDVKIQLDAELKTYQALLEGEEER 386

  Fly   410 LNIT---PATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYY-----VS 466
            ||:|   |...:....|||....::.|          .|||:|.|....||..: ||.     ::
 Worm   387 LNLTQEAPQNTSVHHVSFSSGGASAQR----------GVKRRRVVDVNGEDQDI-DYLNRRSKLN 440

  Fly   467 ASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITV 531
            ....|.|.|.|:|.|||:||:.|...||.:|||::|  ::.......:::|...:::.|:...||
 Worm   441 KETVGPVGIDEVDEEGKWVRVANNSEEEQSIGGYKL--VVKAGNKEASFQFSSRMKLAPHASATV 503

  Fly   532 WSADTKASHEPPSSLVMKSQKWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSV 596
            ||||..|.|.||...|||.|:|...||....|.:|||:.|:                      |:
 Worm   504 WSADAGAVHHPPEVYVMKKQQWPIGDNPSARLEDSEGDTVS----------------------SI 546

  Fly   597 TAVDGNEQLYHQQGDPQQSNEKCAIM 622
            |..      :.:..||....::|:||
 Worm   547 TVE------FSESSDPSDPADRCSIM 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	110/357 (31%)
		Ax_dynein_light	<283..377	CDD:287215	17/93 (18%)
		LTD	466..572	CDD:279300	40/105 (38%)
lmn-1	NP_492371.1	Filament	44..386	CDD:278467	110/358 (31%)
		DUF2317	<57..147	CDD:302887	32/89 (36%)
		LTD	443..547	CDD:279300	42/127 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167842
Domainoid	1	1.000	83	1.000	Domainoid score	I5342
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I1864
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		otm14477
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	LDO	PTHR45721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2618
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840