Protein Alignment Lam and Lmnb2

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_034852.3
• Gene: Lmnb2 / 16907
• MGIID: 96796
• Length: 615
• Species: Mus musculus
• Alignment Length: 651
• Identity: 236/651 - (36%)
• Similarity: 364/651 - (55%)
• Gaps: 76/651 - (11%)

  Fly    11 ATPQPGN--------TS--TPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRL 65
            :.|..||        ||  ...||.|||            ::||||||.||:.||.||:.|||||
Mouse     2 SAPHSGNRGDSPAAATSAMASLPPHAGP------------ATPLSPTRLSRLQEKEELRELNDRL 54

  Fly    66 ATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIK 130
            |.||||||.||.||.||.:.:....:..|||.:.||.::|:||.:.||:||:|||:|||.:|:|.
Mouse    55 AHYIDRVRALELENDRLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIG 119

  Fly   131 RLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERL 195
            ::..|.||.:....|:..|.|.|:|.|:..||..:....:...|.:|::.|..::.|...:|.:.
Mouse   120 KVQAELEEARKSAKKREGELTVAQGRVKDLESLFHRSEAELATALSDKQGLETEVAELRAQLAKA 184

  Fly   196 RKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEY 260
            .......:|.||:|||.||||||..|||:|||:|...:..:|:.|:||..:....|:|.....||
Mouse   185 EDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEY 249

  Fly   261 DAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDAL 325
            |.|:.|:|::||:|::||:::.|.|::..|:.|:...:..:.:...:.|.:.|||:..|:|:::|
Mouse   250 DFKMAQALEDLRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESL 314

  Fly   326 NANINELE-QANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIK 389
            :..:..|: ||:|..| .|.:||..|..:|::..:.:|..|:|:..:|:.|.|||.|||:|:|||
Mouse   315 SYQLLGLQKQASAAEN-HIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIK 378

  Fly   390 VSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAV--------- 445
            ::||:||:||.|||.|||.||.::|:.              |:|.|.||.|.|::.
Mouse   379 LALDMEISAYRKLLEGEEERLKLSPSP--------------SSRITISRATSSSSSSSGVGMSVG 429

  Fly   446 ----KRKRAVVDESEDHSVADYYVSASAKGN-----------VEIKEIDPEGKFVRLFNKGSEEV 495
                ||:|.   |:||.|.:....|..:.|:           |.|.|:||||:||||.|...::.
Mouse   430 QGRGKRRRL---ETEDTSGSPSRASRVSSGSRLAQQTVATGVVNIDEVDPEGRFVRLKNSSDKDQ 491

  Fly   496 AIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQ-KWVSADNT 559
            ::|.|:::|.:.| |....|||.....:.....:|||:|...|:|.|||:||.||| .|...::.
Mouse   492 SLGNWRIKRQVLE-GEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESF 555

  Fly   560 RTILLNSEGEAVANLDRIKRIVSQHTS---SSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAI 621
            ||.|::::||.||    :|  .::|:|   ...........|..|.|.|:||||||:.::..|.:
Mouse   556 RTALVSADGEEVA----VK--AAKHSSVQGRENGEEEEEEEAEFGEEDLFHQQGDPRTTSRGCRL 614

  Fly   622 M 622
            |
Mouse   615 M 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	142/355 (40%)
		LTD	467..572	CDD:460003	41/116 (35%)
Lmnb2	NP_034852.3	Filament	42..398	CDD:459643	142/356 (40%)
		LTD	465..569	CDD:460003	42/108 (39%)