DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lam and Lmnb2

DIOPT Version :9

Sequence 1:NP_001245892.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_034852.3 Gene:Lmnb2 / 16907 MGIID:96796 Length:615 Species:Mus musculus


Alignment Length:651 Identity:236/651 - (36%)
Similarity:364/651 - (55%) Gaps:76/651 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ATPQPGN--------TS--TPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRL 65
            :.|..||        ||  ...||.|||            ::||||||.||:.||.||:.|||||
Mouse     2 SAPHSGNRGDSPAAATSAMASLPPHAGP------------ATPLSPTRLSRLQEKEELRELNDRL 54

  Fly    66 ATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIK 130
            |.||||||.||.||.||.:.:....:..|||.:.||.::|:||.:.||:||:|||:|||.:|:|.
Mouse    55 AHYIDRVRALELENDRLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIG 119

  Fly   131 RLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERL 195
            ::..|.||.:....|:..|.|.|:|.|:..||..:....:...|.:|::.|..::.|...:|.:.
Mouse   120 KVQAELEEARKSAKKREGELTVAQGRVKDLESLFHRSEAELATALSDKQGLETEVAELRAQLAKA 184

  Fly   196 RKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEY 260
            .......:|.||:|||.||||||..|||:|||:|...:..:|:.|:||..:....|:|.....||
Mouse   185 EDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEY 249

  Fly   261 DAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDAL 325
            |.|:.|:|::||:|::||:::.|.|::..|:.|:...:..:.:...:.|.:.|||:..|:|:::|
Mouse   250 DFKMAQALEDLRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESL 314

  Fly   326 NANINELE-QANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIK 389
            :..:..|: ||:|..| .|.:||..|..:|::..:.:|..|:|:..:|:.|.|||.|||:|:|||
Mouse   315 SYQLLGLQKQASAAEN-HIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIK 378

  Fly   390 VSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAV--------- 445
            ::||:||:||.|||.|||.||.::|:.              |:|.|.||.|.|::.         
Mouse   379 LALDMEISAYRKLLEGEEERLKLSPSP--------------SSRITISRATSSSSSSSGVGMSVG 429

  Fly   446 ----KRKRAVVDESEDHSVADYYVSASAKGN-----------VEIKEIDPEGKFVRLFNKGSEEV 495
                ||:|.   |:||.|.:....|..:.|:           |.|.|:||||:||||.|...::.
Mouse   430 QGRGKRRRL---ETEDTSGSPSRASRVSSGSRLAQQTVATGVVNIDEVDPEGRFVRLKNSSDKDQ 491

  Fly   496 AIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQ-KWVSADNT 559
            ::|.|:::|.:.| |....|||.....:.....:|||:|...|:|.|||:||.||| .|...::.
Mouse   492 SLGNWRIKRQVLE-GEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESF 555

  Fly   560 RTILLNSEGEAVANLDRIKRIVSQHTS---SSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAI 621
            ||.|::::||.||    :|  .::|:|   ...........|..|.|.|:||||||:.::..|.:
Mouse   556 RTALVSADGEEVA----VK--AAKHSSVQGRENGEEEEEEEAEFGEEDLFHQQGDPRTTSRGCRL 614

  Fly   622 M 622
            |
Mouse   615 M 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_001245892.1 Filament 54..409 CDD:278467 142/355 (40%)
Ax_dynein_light <283..377 CDD:287215 26/94 (28%)
LTD 466..572 CDD:279300 42/117 (36%)
Lmnb2NP_034852.3 Filament 42..398 CDD:306535 142/356 (40%)
LTD 465..569 CDD:307195 42/108 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 270 1.000 Domainoid score I1818
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7818
Inparanoid 1 1.050 391 1.000 Inparanoid score I1969
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48052
OrthoDB 1 1.010 - - D204815at33208
OrthoFinder 1 1.000 - - FOG0001052
OrthoInspector 1 1.000 - - mtm8905
orthoMCL 1 0.900 - - OOG6_103212
Panther 1 1.100 - - O PTHR45721
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2618
SonicParanoid 1 1.000 - - X632
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1414.010

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