DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lam and Lmna

DIOPT Version :10

Sequence 1:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001002011.2 Gene:Lmna / 16905 MGIID:96794 Length:665 Species:Mus musculus


Alignment Length:596 Identity:220/596 - (36%)
Similarity:355/596 - (59%) Gaps:43/596 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIK 101
            :|.:|:||||||.:|:.||.:||.||||||.||||||:|||||:.|.:.:..:.:.|:||.:.||
Mouse    14 AQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIK 78

  Fly   102 NIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANE 166
            ..:||||.:.|:.||..|::|||.::::.::.||.:|||.:..||..:...|:..::..|:..|.
Mouse    79 AAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNS 143

  Fly   167 LNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKD 231
            .....:.|.::::.|..:|::...::.:|.....|.:|.|:.|.|.|||.||.:|:|:|||.|:.
Mouse   144 KEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQK 208

  Fly   232 QIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQR 296
            .|:|:|:.|::|..:|...|||.....|::::|..:|||||||:|:|::..:.|::..|..|:..
Mouse   209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDN 273

  Fly   297 LQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEI 361
            .:::|.|.||....:.|||:.:|:|||:|:|.:::|::..|...|::||||..|..:|:...:.:
Mouse   274 ARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLL 338

  Fly   362 DLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ 426
            ...|:|:..:|..|.|||.|||:|:|||::||:||.||.|||.|||.||.::|:..       ||
Mouse   339 AEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPT-------SQ 396

  Fly   427 SLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKG 491
            ..|....:..|:.....:|.:||. ::.||..|  .:...|...|.|.::|:|.|||||||.||.
Mouse   397 RSRGRASSHSSQSQGGGSVTKKRK-LESSESRS--SFSQHARTSGRVAVEEVDEEGKFVRLRNKS 458

  Fly   492 SEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQK-WVS 555
            :|:.::|.||::|. |...|..||:|.....::...|:|:|::...|:|.||:.||.|:|. |..
Mouse   459 NEDQSMGNWQIRRQ-NGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGC 522

  Fly   556 ADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAV--------DGNEQLYHQQ--- 609
            ..:.||.|:||.||.||    ::::|            ||:|.|        ||.|.|:|.:   
Mouse   523 GSSLRTALINSTGEEVA----MRKLV------------RSLTMVEDNEDDDEDGEELLHHHRGSH 571

  Fly   610 ----GDPQQSN 616
                |||.:.|
Mouse   572 CSGSGDPAEYN 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_476616.1 Filament 54..409 CDD:459643 139/354 (39%)
LTD 467..572 CDD:460003 43/105 (41%)
LmnaNP_001002011.2 Interaction with MLIP. /evidence=ECO:0000250|UniProtKB:P02545 1..130 54/115 (47%)
Head 1..33 10/18 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 6/10 (60%)
Filament 30..386 CDD:459643 139/355 (39%)
Coil 1A 34..70 20/35 (57%)
Linker 1 71..80 4/8 (50%)
Coil 1B 81..218 44/136 (32%)
Linker 2 219..242 6/22 (27%)
Coil 2 243..383 57/139 (41%)
Tail 384..665 73/226 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..442 17/67 (25%)
Nuclear localization signal. /evidence=ECO:0000255 417..422 2/5 (40%)
LTD 434..541 CDD:460003 45/111 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..577 5/23 (22%)

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