DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and Krt8

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_112447.2	Gene:	Krt8 / 16691	MGIID:	96705	Length:	490	Species:	Mus musculus

Alignment Length:	468	Identity:	128/468 - (27%)
Similarity:	219/468 - (46%)	Gaps:	99/468 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 THSQTASSPL----SPTRHS-RVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVT 94
            |.:|:..|||    .|...: |..||.::::||::.|::||:||.||.:|..|..:....:...|
Mouse    73 TVNQSLLSPLKLEVDPNIQAVRTQEKEQIKSLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKT 137

  Fly    95 RETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRM 159
             ..:|:.|:||:.:...||.|:...:::.:.|.::..:....|:.|||
Mouse   138 -SRSNMDNMFESYINNLRRQLEALGQEKLKLEAELGNMQGLVEDFKNK----------------- 184

  Fly   160 YESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLR 224
            ||   :|:|.:....|                      :|...:|::::..:::|:||:.::.|.
Mouse   185 YE---DEINKRTEMEN----------------------EFVLIKKDVDEAYMNKVELESRLEGLT 224

  Fly   225 EELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQS--LQELRAQYEEQMQINRDEIQ 287
            :|::|..|||.:||.|    .|::.|:....||.:....|...  :.|:|||||:....:|.|.:
Mouse   225 DEINFLRQIHEEEIRE----LQSQISDTSVVLSMDNSRSLDMDGIIAEVRAQYEDIANRSRAEAE 285

  Fly   288 SLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQ-------ANADLNARIRD 345
            ::|:.|.:.||..|.       |..::||.|:..|..:|.|||.|:.       ..|.|.|.|.|
Mouse   286 TMYQIKYEELQTLAG-------KHGDDLRRTKTEISEMNRNINRLQAEIEALKGQRASLEAAIAD 343

  Fly   346 LERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARL 410
            .|::.:...:....::..||..|.|.:::|.:||:|||:||::|::||:||..|.|||.|||:||
Mouse   344 AEQRGEMAIKDAQTKLAELEAALQRAKQDMARQLREYQELMNVKLALDIEITTYRKLLEGEESRL 408

  Fly   411 NI---TPATNTATVQSFSQSLRNSTRA------------------------TPSRRTPSAAVK-- 446
            ..   ..:.:|.|...:|..|.:|...                        |.||.|.:..||
Mouse   409 ESGMQNMSIHTKTTSGYSGGLSSSYGGLTSPGFSYGMSSFQPGFGSAGGSNTFSRTTKAVVVKKI 473

  Fly   447 --RKRAVVDESED 457
              |...:|.||.|
Mouse   474 ETRDGKLVSESSD 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	103/363 (28%)
		Ax_dynein_light	<283..377	CDD:287215	28/100 (28%)
		LTD	466..572	CDD:279300
Krt8	NP_112447.2	Head	1..96		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Keratin_2_head	<69..93	CDD:292825	6/19 (32%)
		Filament	96..407	CDD:278467	103/364 (28%)
		Coil 1A	97..132		13/34 (38%)
		Linker 1	133..149		5/16 (31%)
		Coil 1B	150..241		27/136 (20%)
		Linker 12	242..265		5/22 (23%)
		Coil 2	266..403		50/143 (35%)
		Necessary for interaction with PNN. /evidence=ECO:0000250	267..387		41/126 (33%)
		DUF2570	288..>347	CDD:305162	21/65 (32%)
		Tail	404..490		20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910