DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Krt19

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_032497.1	Gene:	Krt19 / 16669	MGIID:	96693	Length:	403	Species:	Mus musculus

Alignment Length:	379	Identity:	106/379 - (27%)
Similarity:	180/379 - (47%)	Gaps:	81/379 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRE----TTNIKNIFEAELLETRRL 114
            ||:.:||||||||:|:|:||.||..|..|.:::   ||...::    :.:..:.|        :.
Mouse    83 EKITMQNLNDRLASYLDKVRALEQANGELEVKI---RDWYQKQGPGPSRDYNHYF--------KT 136

  Fly   115 LDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRK 179
            ::|.......|.||       |.::..::|           |.|:   .|::...|:...:|.|.
Mouse   137 IEDLRDKILGATID-------NSKIVLQID-----------NARL---AADDFRTKFETEHALRL 180

  Fly   180 KLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRI 244
            .:..|:|              ..|:.|::.||:|.|||..|:||:|||::..:.|.:||...|
Mouse   181 SVEADIN--------------GLRRVLDELTLARTDLEMQIESLKEELAYLKKNHEEEITALR-- 229

  Fly   245 KQTEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTS 305
                 |::.|::|.|.|:    .|.:.|.|:|:|||...:.||.:.::.|..:|:.|     .|.
Mouse   230 -----SQVGGQVSVEVDSTPGVDLAKILSEMRSQYEIMAEKNRKDAEATYLARIEEL-----NTQ 284

  Fly   306 NSTHKSIEELRSTRVRIDALNANINELE---QANADLNARIRDLERQLDNDRERHGQEIDLL--- 364
            .:.|.  |:::.::..:..|...:..||   |:...:.|.   ||..|.....|:|.::..:
Mouse   285 VAVHS--EQIQISKTEVTDLRRTLQGLEIELQSQLSMKAA---LEGTLAETEARYGVQLSQIQSV 344

  Fly   365 ----EKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITP 414
                |.:|..:|.::.:|.:||:.|||||..|:.|||.|..||.|:||..|..|
Mouse   345 ISGFEAQLSDVRADIERQNQEYKQLMDIKSRLEQEIATYRSLLEGQEAHYNNLP 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	103/372 (28%)
		Ax_dynein_light	<283..377	CDD:287215	20/103 (19%)
		LTD	466..572	CDD:279300
Krt19	NP_032497.1	Head	1..82
		Filament	82..393	CDD:278467	103/372 (28%)
		Coil 1A	83..118		19/37 (51%)
		Linker 1	119..136		1/24 (4%)
		Coil 1B	137..228		31/125 (25%)
		Prefoldin	182..307	CDD:238453	41/152 (27%)
		Linker 12	229..251		7/28 (25%)
		BAR	247..>402	CDD:299863	48/162 (30%)
		Necessary for interaction with PNN. /evidence=ECO:0000250	247..393		45/155 (29%)
		Coil 2	252..390		42/147 (29%)
		Rod-like helical tail	391..403		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910