DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Gfap

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_030101431.1	Gene:	Gfap / 14580	MGIID:	95697	Length:	470	Species:	Mus musculus

Alignment Length:	497	Identity:	145/497 - (29%)
Similarity:	230/497 - (46%)	Gaps:	93/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SRRAGTATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSP-TRHSRVAEKVELQNLNDRLATY 68
            ||:.||         .||...:...||.|:....:.:..|:. .:.:|.:|:.|:..||||.|:|
Mouse    25 SRQLGT---------MPRFSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASY 80

  Fly    69 IDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLW 133
            |::||.||.:|..|..|:...|   .:|.|.:.::::|||.|.|..||....:.||.|::.....
Mouse    81 IEKVRFLEQQNKALAAELNQLR---AKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFA 142

  Fly   134 EENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQ 198
            ::...|:.||..:|.....||.|:..|...|:|
Mouse   143 QDLGTLRQKLQDETNLRLEAENNLAAYRQEADE-------------------------------- 175

  Fly   199 FEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRR--IKQTEYSEIDGRLSSEYD 261
                      .||:|||||..::||.||:.|..:|:.:|:.|.|.  .:|..:.|:|       .
Mouse   176 ----------ATLARVDLERKVESLEEEIQFLRKIYEEEVRELREQLAQQQVHVEMD-------V 223

  Fly   262 AK--LKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDA 324
            ||  |..:|:|:|.|||.....|..|.:..|..|...|.:||:|.:....::..|....|.::.|
Mouse   224 AKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDAASRNAELLRQAKHEANDYRRQLQA 288

  Fly   325 LNANINELEQANADLNARIRDLERQLDNDRERHGQE-------IDLLEKELIRLREEMTQQLKEY 382
            |..::..|...|       ..||||:....|||.:|       :..||:|...|:|||.:.|:||
Mouse   289 LTCDLESLRGTN-------ESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEY 346

  Fly   383 QDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ-SLR--NSTRATPSRRTPSAA 444
            |||:::|::||:|||.|.|||.|||.|:       |..||:||. .:|  .||:....::. :..
Mouse   347 QDLLNVKLALDIEIATYRKLLEGEENRI-------TIPVQTFSNLQIRGGKSTKEGEGQKV-TRP 403

  Fly   445 VKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVR 486
            :||....|...:.|.:.:..:.| |:.:::.|.:. ||...|
Mouse   404 LKRLTIQVVPIQAHQIENGALPA-AETSLDTKSVS-EGHLKR 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	115/365 (32%)
		Ax_dynein_light	<283..377	CDD:287215	28/100 (28%)
		LTD	466..572	CDD:279300	6/21 (29%)
Gfap	XP_030101431.1	Filament_head	4..63	CDD:368088	10/46 (22%)
Gfap	XP_030101431.1	Filament	65..373	CDD:365827	115/366 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910