DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lam and KRT72

DIOPT Version :10

Sequence 1:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_542785.1 Gene:KRT72 / 140807 HGNCID:28932 Length:511 Species:Homo sapiens


Alignment Length:499 Identity:124/499 - (24%)
Similarity:228/499 - (45%) Gaps:106/499 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSSKSRR--------AGTATPQPGNTSTPRPPSAGPQPP---PPSTHSQTASSPLS-----PTRH 49
            :|:.:||        .|||....|  ..|:.||.  .||   |..|.:::..:||:     ..:.
Human    60 LSAAARRGGGRLGGFVGTAFGSAG--LGPKCPSV--CPPGGIPQVTVNKSLLAPLNVEMDPEIQR 120

  Fly    50 SRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRE------TTNIKNIFEAEL 108
            .|..|:.:::.||::.|::||:||.||.:|     :|..|:..:.::      ..|::.|:|..:
Human   121 VRAQEREQIKALNNKFASFIDKVRFLEQQN-----QVLETKWNLLQQLDLNNCRKNLEPIYEGYI 180

  Fly   109 LETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQ 173
            ...::.|:..:.|..|.:.:::.:.:..|:.|.:.:.:....|.||                   
Human   181 SNLQKQLEMLSGDGVRLDSELRNMQDLVEDYKKRYEVEINRRTAAE------------------- 226

  Fly   174 ANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEI 238
                                   .:|...:|:::...:::|:|:..:.||.:|:.|...::..||
Human   227 -----------------------NEFVVLKKDVDAAYMNKVELQAKVDSLTDEIKFFKCLYEGEI 268

  Fly   239 NESRRIKQTEYSEIDGRLS--SEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAA 301
            .:.    |:..|:....||  :..|..|...:.|:||||||....::.|.::||:.|||.||..|
Human   269 TQI----QSHISDTSIVLSMDNNRDLDLDSIIAEVRAQYEEIALKSKAEAETLYQTKIQELQVTA 329

  Fly   302 ARTSNSTHKSIEELRSTRVRIDALN-------ANINELEQANADLNARIRDLERQLDNDRERHGQ 359
            .:..       ::|:.|:..|..||       :.|..:::..|||...|.|.|::.|...:....
Human   330 GQHG-------DDLKLTKAEISELNRLIQRIRSEIGNVKKQCADLETAIADAEQRGDCALKDARA 387

  Fly   360 EIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEAR----------LNITP 414
            ::|.||..|.:.:||:.:.|:|||:|:.:|::||:|||.|.|||..||.|          :::..
Human   388 KLDELEGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYPNSVSISVIS 452

  Fly   415 ATNT-ATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESED 457
            :||. |....||.....|  ::.|.:|.:|.||.|.:...|.:|
Human   453 STNAGAGGAGFSMGFGAS--SSYSYKTAAADVKTKGSCGSELKD 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_476616.1 Filament 54..409 CDD:459643 92/369 (25%)
LTD 467..572 CDD:460003
KRT72NP_542785.1 Head 1..124 17/67 (25%)
Keratin_2_head 15..121 CDD:465068 16/64 (25%)
Filament 124..437 CDD:459643 92/370 (25%)
Coil 1A 125..160 13/39 (33%)
Linker 1 161..179 3/17 (18%)
Coil 1B 180..271 18/132 (14%)
Linker 12 272..295 6/22 (27%)
Coil 2 296..434 50/144 (35%)
Tail 435..511 16/62 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..511 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

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