DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and vim

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_571947.1	Gene:	vim / 140599	ZFINID:	ZDB-GENE-011212-3	Length:	455	Species:	Danio rerio

Alignment Length:	427	Identity:	119/427 - (27%)
Similarity:	214/427 - (50%)	Gaps:	78/427 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PPSTHSQ-----TASSPL-----------------SPTRHSRVAEKVELQNLNDRLATYIDRVRN 74
            |||.::.     .:.:||                 :..:.:|..||.|:|:||||.|:|||:||.
Zfish    50 PPSVYASKGLRVRSGAPLPRLATDTLDFGLAEAINTEFKANRTNEKAEMQHLNDRFASYIDKVRF 114

  Fly    75 LETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEEL 139
            ||.:|..|..|::..|.   :..:.:.:::|.|:.|.||.:|....::::.|:|...|.|:.|.|
Zfish   115 LEQQNKILIAELEQLRG---KGASRVGDLYEDEMRELRRQVDQLTGEKSKVEVDRDNLGEDIERL 176

  Fly   140 KNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRK 204
            |.:|.::..:...||.::|.:                                          |:
Zfish   177 KERLQEEMLQREDAENSLRSF------------------------------------------RQ 199

  Fly   205 NLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQ 269
            :::..:|:|:|||..::||:||::|..::|.:|:.|.:...|.::.:||..::.   ..|..:|:
Zfish   200 DVDNASLARLDLERKVESLQEEIAFLKKLHDEELAEMQIQMQEQHLQIDMEVTK---PDLTAALK 261

  Fly   270 ELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQ 334
            ::|.|||.....|..|.:..|:.|...|.|||||.:.:...:.:|....|.::.||..::..|:.
Zfish   262 DVRQQYETLASRNLQESEDWYKSKFADLSEAAARNNEAIRLAKQEANDYRRQLQALTCDLEALKG 326

  Fly   335 ANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAY 399
            .|..|..::|:||.....:...:...|..||.::..:::||.:.|:|||||:::|::||:|||.|
Zfish   327 TNESLERQMRELEDSFSMEASGYQDTIGRLEDDIRNMKDEMARHLREYQDLLNVKMALDIEIATY 391

  Fly   400 DKLLVGEEARLNITPATNTATVQSFSQ-SLRNSTRAT 435
            .|||.|||:|:       |:...:||. |||.|.:.|
Zfish   392 RKLLEGEESRI-------TSPFPNFSSLSLRESMKET 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	104/354 (29%)
		Ax_dynein_light	<283..377	CDD:287215	24/93 (26%)
		LTD	466..572	CDD:279300
vim	NP_571947.1	Filament_head	5..92	CDD:282575	5/41 (12%)
vim	NP_571947.1	Filament	93..401	CDD:278467	104/355 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810