DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and Des

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_034173.1	Gene:	Des / 13346	MGIID:	94885	Length:	469	Species:	Mus musculus

Alignment Length:	471	Identity:	135/471 - (28%)
Similarity:	227/471 - (48%)	Gaps:	82/471 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKSRRAGTATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLA 66
            |.:|.|.||.          |.||.|.......:.:...:.....||.:   ||||||.||||.|
Mouse    68 SLRSSRLGTT----------RAPSYGAGELLDFSLADAVNQEFLATRTN---EKVELQELNDRFA 119

  Fly    67 TYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKR 131
            .||::||.||.:|:.|..||...:.   ||.|.:..::|.|:.|.||.::.....|||.:::...
Mouse   120 NYIEKVRFLEQQNAALAAEVNRLKG---REPTRVAELYEEEMRELRRQVEVLTNQRARVDVERDN 181

  Fly   132 LWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLR 196
            |.::.:.||.||.::.:....||.|:..:
Mouse   182 LIDDLQRLKAKLQEEIQLREEAENNLAAF------------------------------------ 210

  Fly   197 KQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYD 261
                  |.:::..||:|:|||..|:||.||::|..::|.:||.|.:...|.:..:::..:|.
Mouse   211 ------RADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSK--- 266

  Fly   262 AKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALN 326
            ..|..:|:::|||||.....|..|.:..|:.|:..|.:||.:.:::..::.:|:...|.:|.:..
Mouse   267 PDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYT 331

  Fly   327 ANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVS 391
            ..|:.|:..|..|..::|:||.:..::...:...|..||:|:..|::||.:.|:|||||:::|::
Mouse   332 CEIDALKGTNDSLMRQMRELEDRFASEANGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMA 396

  Fly   392 LDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVK---------- 446
            ||:|||.|.|||.|||:|:|:       .:|:|  |..|....:|.:|......|
Mouse   397 LDVEIATYRKLLEGEESRINL-------PIQTF--SALNFRETSPEQRGSEVHTKKTVMIKTIET 452

  Fly   447 RKRAVVDES--EDHSV 460
            |...||.|:  :.|.|
Mouse   453 RDGEVVSEATQQQHEV 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	109/354 (31%)
		Ax_dynein_light	<283..377	CDD:287215	23/93 (25%)
		LTD	466..572	CDD:279300
Des	NP_034173.1	Head	2..108		11/52 (21%)
		Filament_head	9..105	CDD:282575	10/46 (22%)
		Filament	106..414	CDD:278467	109/358 (30%)
		Coil 1A	109..140		18/30 (60%)
		Linker 1	141..150		3/11 (27%)
		Coil 1B	151..251		33/141 (23%)
		Linker 12	252..267		2/17 (12%)
		Interaction with NEB. /evidence=ECO:0000250\|UniProtKB:P17661	267..414		50/146 (34%)
		Coil 2A	268..286		7/17 (41%)
		Linker 2	287..294		2/6 (33%)
		Coil 2B	295..411		38/115 (33%)
		Tail	412..469		16/66 (24%)
		Interaction with CRYAB. /evidence=ECO:0000250\|UniProtKB:P17661	437..452		1/14 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810