Protein Alignment Lam and KRT71

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_258259.1
• Gene: KRT71 / 112802
• HGNCID: 28927
• Length: 523
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 117/474 - (24%)
• Similarity: 216/474 - (45%)
• Gaps: 86/474 - (18%)

  Fly    31 PPPSTHSQTAS-SPLSP--------TRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEV 86
            ||...|..|.: |.|:|        .:..|..|:.:::.||::.|::||:||.||.:|..|..:.
Human    98 PPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKW 162

  Fly    87 QTTRDTVTRETTNIKN----IFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKT 147
            :..:..   :..|.||    |.|..:...|:.|:..:.||.|.:.:::.:.:..|:.|.:.:::.
Human   163 ELLQQL---DLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEI 224

  Fly   148 KECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLS 212
            .:.|.||                                          .:|...:|:::....:
Human   225 NKRTAAE------------------------------------------NEFVLLKKDVDAAYAN 247

  Fly   213 RVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAK--LKQSLQELRAQY 275
            :|:|:..::|:.:|:.|...:...||.:.    |:..|::...||.:.:..  |...:.|:|.||
Human   248 KVELQAKVESMDQEIKFFRCLFEAEITQI----QSHISDMSVILSMDNNRNLDLDSIIDEVRTQY 308

  Fly   276 EEQMQINRDEIQSLYEDKIQRLQEAAARTSN---STHKSIEELRSTRVRIDALNANINELEQANA 337
            ||....::.|.::||:.|.|.||.||.|..:   :|...|.||  ||: |..:.:.|..:::..:
Human   309 EEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISEL--TRL-IQRIRSEIENVKKQAS 370

  Fly   338 DLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKL 402
            :|...|.|.|::.||..:....::|.||..|.:.:||:.:.|:|||:||.:|::||:|||.|.||
Human   371 NLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKL 435

  Fly   403 LVGEEAR----------LNITPATNTATVQSFSQSL------RNSTRATPSRRTPSAAVKRKRAV 451
            |..||.|          ::|..:|:..:|..|..|:      .||:.......:......|.|..
Human   436 LESEECRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGS 500

  Fly   452 VDESEDHSVADYYVSASAK 470
            .::.:|.......:||.:|
Human   501 ANDYKDTLGKGSSLSAPSK 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	95/363 (26%)
		LTD	467..572	CDD:460003	2/4 (50%)
KRT71	NP_258259.1	Head	1..129		8/30 (27%)
		Keratin_2_head	16..126	CDD:465068	7/27 (26%)
		Filament	129..442	CDD:459643	95/364 (26%)
		Coil 1A	130..165		12/34 (35%)
		Linker 1	166..184		5/20 (25%)
		Coil 1B	185..276		19/132 (14%)
		Linker 12	277..300		5/22 (23%)
		Coil 2	301..439		52/140 (37%)
		Tail	440..523		15/80 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..523		6/28 (21%)