DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and krt7

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_002935788.2	Gene:	krt7 / 100101751	XenbaseID:	XB-GENE-876869	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	414	Identity:	109/414 - (26%)
Similarity:	209/414 - (50%)	Gaps:	70/414 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 THSQTASSPLS----PT-RHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVT 94
            |.:|:..:||:    || :|.|..|:.:::.||::.|::||:||.||.:|..|..:.:..::..:
Frog   111 TINQSLLAPLNLEIDPTIQHVRQEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQNQKS 175

  Fly    95 RETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRM 159
            .:.:|:..:|:|.:...||.||....|:.:.|.:::.:.:..|:.|||.:.:..:.|:||
Frog   176 AKASNVGPLFDAYIANLRRQLDGLTGDKGKLEGELRNMQDLVEDFKNKYEDEINKRTSAE----- 235

  Fly   160 YESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLR 224
                                                 .:|...:|:::...:::|:||..:::|.
Frog   236 -------------------------------------NEFVVLKKDVDAAYMNKVELEAKMEALT 263

  Fly   225 EELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQS--LQELRAQYEEQMQINRDEIQ 287
            :|::|...::..|:.|    .|.:.|:....||.:.:..|...  :.|::||||:....:|...:
Frog   264 DEINFLRALYEAELRE----LQEQISDTSVVLSMDNNRALDMDSIIAEVKAQYEDIANKSRANAE 324

  Fly   288 SLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDN 352
            ::|::|.|.||..|.|..       ::||:|:..|..||..:..|:.....:.|:...||.|:..
Frog   325 AVYQNKFQELQATAGRHG-------DDLRTTKTEISELNRAMQRLQAEIESVKAQRAKLEAQIAE 382

  Fly   353 DRERHGQ--------EIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEAR 409
            ..|| |:        ::..||..|.:.:::|.:||:|||:||::|::||:|||.|.|||.|||.|
Frog   383 AEER-GELALKDARTKLAELEAALQKAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEETR 446

  Fly   410 LNITPA-TNTATVQSFSQSLRNST 432
            ::..|. .:.:.|.|.|.|:..|:
Frog   447 ISEGPGPVSVSVVNSTSSSMGGSS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	94/364 (26%)
		Ax_dynein_light	<283..377	CDD:287215	26/101 (26%)
		LTD	466..572	CDD:279300
krt7	XP_002935788.2	Keratin_2_head	<106..131	CDD:374433	6/19 (32%)
krt7	XP_002935788.2	Filament	134..446	CDD:365827	94/365 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910