DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel25E and UAP56b

DIOPT Version :9

Sequence 1:	NP_723089.1	Gene:	Hel25E / 33781	FlyBaseID:	FBgn0014189	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001154706.1	Gene:	UAP56b / 830990	AraportID:	AT5G11200	Length:	486	Species:	Arabidopsis thaliana

Alignment Length:	481	Identity:	295/481 - (61%)
Similarity:	352/481 - (73%)	Gaps:	66/481 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADNDDLLDYEDEEQ--TETTAVENQEAPKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCGFEHP 64
            |..::|||||:|::  .::....|.||.||.    ||.||||||||||||||:||||||.|||||
plant     9 AYEEELLDYEEEDEKVPDSGNKVNGEAVKKG----YVGIHSSGFRDFLLKPELLRAIVDSGFEHP 69

  Fly    65 SEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELAFQISKE 129
            |||||||||||:||||::|||||||||||||||:||||:|||.... ..||:|||||||:||..|
plant    70 SEVQHECIPQAILGMDVICQAKSGMGKTAVFVLSTLQQIEPSPGQV-SALVLCHTRELAYQICNE 133

  Fly   130 YERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKKLNLKLLKHFVLDE 194
            :.|||.|:|..||:||:||:.|:..::.||:..||||||||||:|||.|.|.|:||.::||:|||
plant   134 FVRFSTYLPDTKVSVFYGGVNIKIHKDLLKNECPHIVVGTPGRVLALAREKDLSLKNVRHFILDE 198

  Fly   195 CDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQD----------------- 242
            ||||||.|||||||||||:.|||.||||||||||||:|||||||||||
plant   199 CDKMLESLDMRRDVQEIFKMTPHDKQVMMFSATLSKEIRPVCKKFMQDFLENETVSVRLFSFGVE 263

  Fly   243 ------------------------------------------PMEVYVDDEAKLTLHGLQQHYVN 265
                                                      |||:|||||||||||||.|||:.
plant   264 NSEWRLCSFGFIVLVWVSMFRAILMFHSKTHIFEEKRWTRISPMEIYVDDEAKLTLHGLVQHYIK 328

  Fly   266 LKENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIHRGMTQEERLNRYQQF 330
            |.|.|||:||.:|||.|:|||||||||||.|...|::||.|.|||:|.||.||:|||||.||:.|
plant   329 LSEMEKNRKLNDLLDALDFNQVVIFVKSVSRAAELNKLLVECNFPSICIHSGMSQEERLTRYKSF 393

  Fly   331 KDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAK 395
            |:..|||||||:|.|||:||||||||.|||||:.:|||||||.|||||||||||||||:..:|::
plant   394 KEGHKRILVATDLVGRGIDIERVNIVINYDMPDSADTYLHRVGRAGRFGTKGLAITFVASASDSE 458

  Fly   396 ILNEVQDRFDVNISELPEEIDLSTYI 421
            :||:||:||:|:|.||||:||.|||:
plant   459 VLNQVQERFEVDIKELPEQIDTSTYM 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	155/266 (58%)
Hel25E	NP_723089.1	SF2_C_DEAD	259..388	CDD:350174	92/128 (72%)
UAP56b	NP_001154706.1	DEADc_DDX39	45..249	CDD:350708	152/204 (75%)
UAP56b	NP_001154706.1	PRK11776	53..476	CDD:236977	264/423 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	244	1.000	Domainoid score	I563
eggNOG	1	0.900	-	-		E2759_KOG0329
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I229
OMA	1	1.010	-	-		QHG54017
OrthoDB	1	1.010	-	-		D779000at2759
OrthoFinder	1	1.000	-	-		FOG0001601
OrthoInspector	1	1.000	-	-		otm3068
orthoMCL	1	0.900	-	-		OOG6_101150
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1003
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840