Protein Alignment Hel25E and DDX19A

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_060802.1
• Gene: DDX19A / 55308
• HGNCID: 25628
• Length: 478
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 138/448 - (30%)
• Similarity: 231/448 - (51%)
• Gaps: 41/448 - (9%)

  Fly     2 ADNDDLL------DYEDEEQTETTAVE---------------NQ-EAPKKDVKGTYVSIHSSGFR 44
            ||.:.::      :..|||:.|..|.:               || |..::|......|:.|  |.
Human    32 ADTNGIIKTSTTAEKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKS--FE 94

  Fly    45 DFLLKPEILRAIVDCGFEHPSEVQHECIPQ--AVLGMDILCQAKSGMGKTAVFVLATLQQLEPSD 107
            :..|||::|:.:...||..||::|...:|.  |....:::.|::||.||||.||||.|.::||||
Human    95 ELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPSD 159

  Fly   108 NNTCHVLVMCHTRELAFQISKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGR 172
            ... ..|.:..|.|||.|..|..|:..|:.|.:|:|....|..:::.::.    :..||:||||.
Human   160 RYP-QCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKI----SEQIVIGTPGT 219

  Fly   173 ILALIRNKK-LNLKLLKHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVC 236
            :|......| ::.|.:|.|||||.|.|:.....:.....|.|..|...|:::||||....:....
Human   220 VLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFA 284

  Fly   237 KKFMQDPMEVYVDDEAKLTLHGLQQHYVNL-KENEKNKKLFELLDVLEFNQVVIFVKSVQRCVAL 300
            :|.:.||..:.:..|.: ||..::|:||.. ..:||.:.|..|...:...|.:||..:.:....|
Human   285 QKVVPDPNVIKLKREEE-TLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWL 348

  Fly   301 SQLLTEQNFPAIGIHRGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDS 365
            :..|:::......:...|..|:|....::|::.::::||.||:..||:|:|:|::|.|:|:|.|.
Human   349 AAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDK 413

  Fly   366 D------TYLHRVARAGRFGTKGLAITFVSDENDAKILNEVQDRFDVNISEL-PEEID 416
            |      |||||:.|.||||.:|||:..|..::...|||.:|:.|:..|..| .:::|
Human   414 DGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLD 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	70/210 (33%)
		SF2_C_DEAD	259..388	CDD:350174	44/135 (33%)
DDX19A	NP_060802.1	N-terminal lobe. /evidence=ECO:0000250	2..299		82/273 (30%)
		N-terminal helix. /evidence=ECO:0000250	54..67		1/12 (8%)
		DEAD-like_helicase_N	74..302	CDD:475120	76/235 (32%)
		Q motif	91..119		10/29 (34%)
		DEAD box	241..244		2/2 (100%)
		C-terminal lobe. /evidence=ECO:0000250	300..478		55/173 (32%)
		SF2_C_DEAD	306..442	CDD:350174	44/135 (33%)