DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel25E and pit

DIOPT Version :9

Sequence 1:	NP_723089.1	Gene:	Hel25E / 33781	FlyBaseID:	FBgn0014189	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	127/443 - (28%)
Similarity:	218/443 - (49%)	Gaps:	52/443 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADNDDLLDYEDEEQ----TETTAVENQE-----APKKD-----VKGTYVSI--HSSGFRDFL-LK 49
            :::||..:.||||:    .:|..:.|:.     .|.||     |:.:..::  ..|..|.|. ||
  Fly   127 SEDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLK 191

  Fly    50 PEI----LRAIVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQ---QLEPSD 107
            ..:    ||||.:.||...:|:|.:.:...:.|.|::..|::|.|||..|::..::   :|....
  Fly   192 GAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMP 256

  Fly   108 NNTCHVLVMCHTRELAFQ---ISKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGT 169
            .|...|:::..||||:.|   :.||......:    ...:..||...|.:.|.|..|. :|:|.|
  Fly   257 RNGTGVIIISPTRELSMQTFGVLKELMAHHHH----TYGLVMGGSNRQVESEKLGKGI-NILVAT 316

  Fly   170 PGRILALIRNKKLNL-KLLKHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIR 233
            |||:|..::|....| |.|:..::||.|::|| :....::::|....|..:|.|:||||.:..|.
  Fly   317 PGRLLDHLQNSPDFLYKNLQCLIIDEVDRILE-IGFEEELKQIINLLPKRRQTMLFSATQTARIE 380

  Fly   234 PVCKKFMQ-DPMEVYV-DDEAKLTLHGLQQHYVNLKENEKNKKLFELLDVLEFNQVVIFVKSVQR 296
            .:.|..:: :|:.|.| |::...|:.||:|.|:.....::...||..|......:|::|..|
  Fly   381 ALSKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFTFLKKNRKKKVMVFFSS--- 442

  Fly   297 CVALS---QLLTEQNFPAIGIHRGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFN 358
            |:::.   :|....:.|...||....|.:|...:.||.:.:..||:.|::..||:||.:|:.:..
  Fly   443 CMSVKYHHELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQ 507

  Fly   359 YDMPEDSDTYLHRVARAGR-FGTKGLAITFVSDE--------NDAKI-LNEVQ 401
            ||.|:|...|:|||.|..| .||.|.|:..:..|        ..||: |||.:
  Fly   508 YDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKAAKVPLNEFE 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	65/220 (30%)
Hel25E	NP_723089.1	SF2_C_DEAD	259..388	CDD:350174	40/132 (30%)
pit	NP_001287459.1	SrmB	186..677	CDD:223587	113/384 (29%)
		DEADc	187..394	CDD:238167	62/212 (29%)
		HELICc	408..537	CDD:238034	40/131 (31%)
		DUF4217	569..627	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930