DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel25E and ddx39b

DIOPT Version :9

Sequence 1:	NP_723089.1	Gene:	Hel25E / 33781	FlyBaseID:	FBgn0014189	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_989072.1	Gene:	ddx39b / 394669	XenbaseID:	XB-GENE-478336	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	432	Identity:	359/432 - (83%)
Similarity:	393/432 - (90%)	Gaps:	17/432 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADND---DLLDYEDEEQTETTAVENQ---EAP----KKDVKGTYVSIHSSGFRDFLLKPEILRA 55
            ||:.|   :||||||:|      |:||   :||    ||::||:|||||||||||||||||:|||
Frog     1 MAETDVDNELLDYEDDE------VDNQAGVDAPDITVKKEMKGSYVSIHSSGFRDFLLKPELLRA 59

  Fly    56 IVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTR 120
            ||||||||||||||||||||:|||||||||||||||||||||||||||||..... .||||||||
Frog    60 IVDCGFEHPSEVQHECIPQAILGMDILCQAKSGMGKTAVFVLATLQQLEPVTGQV-SVLVMCHTR 123

  Fly   121 ELAFQISKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKKLNLK 185
            ||||||||||||||||||:|||||||||:||:||||.||...||||||||||:|||.|||.||||
Frog   124 ELAFQISKEYERFSKYMPSVKVAVFFGGLAIKKDEEVLKKSCPHIVVGTPGRMLALARNKTLNLK 188

  Fly   186 LLKHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDD 250
            .:|||:||||||||||||||||||||||.|||.||||||||||||:|||||:||||||||::|||
Frog   189 HIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDD 253

  Fly   251 EAKLTLHGLQQHYVNLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIH 315
            |.|||||||||:||.||:||||:|||:|||:||||||||||||||||:||:|||.|||||||.||
Frog   254 ETKLTLHGLQQYYVKLKDNEKNRKLFDLLDLLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIH 318

  Fly   316 RGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGT 380
            |||:|||||:|||||||||:||||||||||||||||||||.||||||||||||||||||||||||
Frog   319 RGMSQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGT 383

  Fly   381 KGLAITFVSDENDAKILNEVQDRFDVNISELPEEIDLSTYIE 422
            |||||||||||.||||||||||||:|||||||:|||:|:|||
Frog   384 KGLAITFVSDEGDAKILNEVQDRFEVNISELPDEIDISSYIE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	180/207 (87%)
Hel25E	NP_723089.1	SF2_C_DEAD	259..388	CDD:350174	114/128 (89%)
ddx39b	NP_989072.1	DEADc_DDX39	44..251	CDD:350708	180/207 (87%)
ddx39b	NP_989072.1	SF2_C_DEAD	262..391	CDD:350174	114/128 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1602
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48376
Inparanoid	1	1.050	709	1.000	Inparanoid score	I642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274153at33208
OrthoFinder	1	1.000	-	-		FOG0001601
OrthoInspector	1	1.000	-	-		otm48424
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1003
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060