DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel25E and uap56

DIOPT Version :9

Sequence 1:	NP_723089.1	Gene:	Hel25E / 33781	FlyBaseID:	FBgn0014189	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_594261.1	Gene:	uap56 / 2542433	PomBaseID:	SPAC17G6.14c	Length:	434	Species:	Schizosaccharomyces pombe

Alignment Length:	428	Identity:	286/428 - (66%)
Similarity:	346/428 - (80%)	Gaps:	12/428 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDLLDYEDEE--------QTETTAVENQE-APKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCG 60
            :||:|||:||        |..|.|.:..| ..|.|.||:||.|||:||||||||||:||||.|.|
pombe     6 EDLIDYEEEEELVQDQPAQEITPAADTAENGEKSDKKGSYVGIHSTGFRDFLLKPELLRAITDSG 70

  Fly    61 FEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELAFQ 125
            ||||||||..||||::||.|:||||||||||||||||:||||:||.|... .|||:|||||||||
pombe    71 FEHPSEVQQVCIPQSILGTDVLCQAKSGMGKTAVFVLSTLQQIEPVDGEV-SVLVLCHTRELAFQ 134

  Fly   126 ISKEYERFSKYMPTVKVAVFFGGMAIQKDEETL--KSGTPHIVVGTPGRILALIRNKKLNLKLLK 188
            |..||.|||||:|.|:.|||:||:.|::|.|..  ||.:|||||.||||:.||:|.|.|.:..:|
pombe   135 IKNEYARFSKYLPDVRTAVFYGGINIKQDMEAFKDKSKSPHIVVATPGRLNALVREKILKVNSVK 199

  Fly   189 HFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEAK 253
            |||||||||:||.:|||||:||:||:||..|||||||||||.:|||:||||||:|:|:|||||.|
pombe   200 HFVLDECDKLLESVDMRRDIQEVFRATPPQKQVMMFSATLSNEIRPICKKFMQNPLEIYVDDETK 264

  Fly   254 LTLHGLQQHYVNLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIHRGM 318
            |||||||||||.|:|..||:|:.:|||.|||||||||||||.|...|.:||.|.|||:|.||.|:
pombe   265 LTLHGLQQHYVKLEEKAKNRKINDLLDSLEFNQVVIFVKSVSRANELDRLLRECNFPSICIHGGL 329

  Fly   319 TQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGL 383
            .||||:.||:.||||.|||.|||::||||:||||||||.|||||:..|:|||||.||||||||||
pombe   330 PQEERIKRYKAFKDFDKRICVATDVFGRGIDIERVNIVINYDMPDSPDSYLHRVGRAGRFGTKGL 394

  Fly   384 AITFVSDENDAKILNEVQDRFDVNISELPEEIDLSTYI 421
            ||||.|.|.|::||:::|:||:|||:|||:|||:.:|:
pombe   395 AITFSSSEEDSQILDKIQERFEVNITELPDEIDVGSYM 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	146/209 (70%)
Hel25E	NP_723089.1	SF2_C_DEAD	259..388	CDD:350174	91/128 (71%)
uap56	NP_594261.1	PTZ00424	53..426	CDD:185609	261/373 (70%)
		DEADc	53..257	CDD:238167	143/204 (70%)
		HELICc	272..398	CDD:238034	88/125 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	230	1.000	Domainoid score	I506
eggNOG	1	0.900	-	-		E2759_KOG0329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48376
Inparanoid	1	1.050	575	1.000	Inparanoid score	I175
OMA	1	1.010	-	-		QHG54017
OrthoFinder	1	1.000	-	-		FOG0001601
OrthoInspector	1	1.000	-	-		oto101156
orthoMCL	1	0.900	-	-		OOG6_101150
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1410
SonicParanoid	1	1.000	-	-		X1003
TreeFam	1	0.960	-	-
	14	13.860