Protein Alignment Hel25E and EIF4A1

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001407.1
• Gene: EIF4A1 / 1973
• HGNCID: 3282
• Length: 406
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 140/387 - (36%)
• Similarity: 226/387 - (58%)
• Gaps: 7/387 - (1%)

  Fly    27 PKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGK 91
            |:..::..:..|..| |.|..|...:||.|...|||.||.:|...|...:.|.|::.||:||.||
Human    19 PEGVIESNWNEIVDS-FDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGK 82

  Fly    92 TAVFVLATLQQLEPSDNNTCHVLVMCHTRELAFQISKEYERFSKYMPTVKVAVFFGGMAIQKDEE 156
            ||.|.::.|||:| .|......||:..|||||.||.|.......|| ........||..::.:.:
Human    83 TATFAISILQQIE-LDLKATQALVLAPTRELAQQIQKVVMALGDYM-GASCHACIGGTNVRAEVQ 145

  Fly   157 TLKSGTPHIVVGTPGRILALIRNKKLNLKLLKHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQV 221
            .|:...|||:||||||:..::..:.|:.|.:|.|||||.|:||.: ..:..:.:||:......||
Human   146 KLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSR-GFKDQIYDIFQKLNSNTQV 209

  Fly   222 MMFSATLSKDIRPVCKKFMQDPMEVYVDDEAKLTLHGLQQHYVNLKENE-KNKKLFELLDVLEFN 285
            ::.|||:..|:..|.||||:||:.:.|..| :|||.|::|.|:|::..| |...|.:|.:.|...
Human   210 VLLSATMPSDVLEVTKKFMRDPIRILVKKE-ELTLEGIRQFYINVEREEWKLDTLCDLYETLTIT 273

  Fly   286 QVVIFVKSVQRCVALSQLLTEQNFPAIGIHRGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDI 350
            |.|||:.:.::...|::.:..::|....:|..|.|:||....::|:....|:|:.|:|..||:|:
Human   274 QAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDV 338

  Fly   351 ERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNEVQDRFDVNISELP 412
            ::|::|.|||:|.:.:.|:||:.|.||||.||:||..|::| |.:.|.:::..::.:|.|:|
Human   339 QQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEE-DKRTLRDIETFYNTSIEEMP 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	80/207 (39%)
		SF2_C_DEAD	259..388	CDD:350174	45/129 (35%)
EIF4A1	NP_001407.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		1/1 (100%)
		DEAD-like_helicase_N	20..406	CDD:475120	139/386 (36%)
		Q motif	32..60		12/28 (43%)
		DEAD box	182..185		2/2 (100%)