Protein Alignment Hel25E and eif-4A3

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001370755.1
• Gene: eif-4A3 / 190485
• WormBaseID: WBGene00022029
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 413
• Identity: 144/413 - (34%)
• Similarity: 227/413 - (54%)
• Gaps: 26/413 - (6%)

  Fly     4 NDDLLDYEDEEQTETTAVENQEAPKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCGFEHPSEVQ 68
            |||:...|.|...|.:.:     |..|..|              |:.::||.|...|||.||.:|
 Worm     8 NDDMATVEFESSEEVSII-----PTFDKMG--------------LREDLLRGIYAYGFEKPSAIQ 53

  Fly    69 HECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELAFQISKEYERF 133
            ...||..:...|::.||:||.||||.|.::.||.|:.....| ..|::..|||||.||.|.....
 Worm    54 QRAIPAILKARDVIAQAQSGTGKTATFSISVLQSLDTQVRET-QALILSPTRELAVQIQKVVLAL 117

  Fly   134 SKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKKLNLKLLKHFVLDECDKM 198
            ..|| .|:.....||..:.:|...|..| .|:|.|||||:..:||.:.|..:.:|..||||.|:|
 Worm   118 GDYM-NVQCHACIGGTNLGEDIRKLDYG-QHVVSGTPGRVFDMIRRRNLRTRAIKLLVLDEADEM 180

  Fly   199 LEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEAKLTLHGLQQHY 263
            |.: ..:..:.:|:|..|.|.||::.||||..:|..:..|||.||:.:.|..: :|||.|::|.:
 Worm   181 LNK-GFKEQLYDIYRYLPPGAQVVLLSATLPHEILEMTSKFMTDPIRILVKRD-ELTLEGIKQFF 243

  Fly   264 VNL-KENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIHRGMTQEERLNRY 327
            |.: :|..|...|.:|.|.|...|.|:|..:.::...|:..:.|.||....:|..|.|::|....
 Worm   244 VAVDREEWKFDTLIDLYDTLTITQAVLFCNTRRKVDWLTDKMKEANFTVSSMHGDMEQKDRDEVM 308

  Fly   328 QQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDEN 392
            ::|:....|:|::|:::.||:|:.:|::|.|||:|.:.:.|:||:.|:||||.||:||.||. ::
 Worm   309 KEFRAGTTRVLISTDVWARGLDVPQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVAINFVK-QD 372

  Fly   393 DAKILNEVQDRFDVNISELPEEI 415
            |.:||.:::..:...|.|:|..|
 Worm   373 DVRILRDIEQYYSTQIDEMPMNI 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	77/207 (37%)
		SF2_C_DEAD	259..388	CDD:350174	44/129 (34%)
eif-4A3	NP_001370755.1	DEAD-like_helicase_N	1..399	CDD:475120	144/413 (35%)