Protein Alignment Hel25E and Eif4a2

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001334108.1
• Gene: Eif4a2 / 13682
• MGIID: 106906
• Length: 408
• Species: Mus musculus
• Alignment Length: 374
• Identity: 143/374 - (38%)
• Similarity: 224/374 - (59%)
• Gaps: 6/374 - (1%)

  Fly    43 FRDFLLKPEILRAIVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSD 107
            |.|..||..:||.|...|||.||.:|...|...:.|.|::.||:||.||||.|.::.|||||...
Mouse    36 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEF 100

  Fly   108 NNTCHVLVMCHTRELAFQISKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGR 172
            ..| ..||:..|||||.||.|.......||.....|. .||..::.:.:.|::..||||||||||
Mouse   101 KET-QALVLAPTRELAQQIQKVILALGDYMGATCHAC-IGGTNVRNEMQKLQAEAPHIVVGTPGR 163

  Fly   173 ILALIRNKKLNLKLLKHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCK 237
            :..::..:.|:.|.:|.|||||.|:||.: ..:..:.|||:......||::.|||:..|:..|.|
Mouse   164 VFDMLNRRYLSPKWIKMFVLDEADEMLSR-GFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTK 227

  Fly   238 KFMQDPMEVYVDDEAKLTLHGLQQHYVNLKENE-KNKKLFELLDVLEFNQVVIFVKSVQRCVALS 301
            |||:||:.:.|..| :|||.|::|.|:|::..| |...|.:|.:.|...|.|||:.:.::...|:
Mouse   228 KFMRDPIRILVKKE-ELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLT 291

  Fly   302 QLLTEQNFPAIGIHRGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSD 366
            :.:..::|....:|..|.|:||....::|:....|:|:.|:|..||:|:::|::|.|||:|.:.:
Mouse   292 EKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRE 356

  Fly   367 TYLHRVARAGRFGTKGLAITFVSDENDAKILNEVQDRFDVNISELPEEI 415
            .|:||:.|.||||.||:||.||::| |.:||.:::..::..:.|:|..:
Mouse   357 NYIHRIGRGGRFGRKGVAINFVTEE-DKRILRDIETFYNTTVEEMPMNV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	84/204 (41%)
		SF2_C_DEAD	259..388	CDD:350174	45/129 (35%)
Eif4a2	NP_001334108.1	DEAD-like_helicase_N	9..408	CDD:475120	143/374 (38%)
		Q motif	34..62		12/25 (48%)
		DEAD box	184..187		2/2 (100%)