Protein Alignment Hel25E and Ddx19a

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_031942.2
• Gene: Ddx19a / 13680
• MGIID: 99526
• Length: 478
• Species: Mus musculus
• Alignment Length: 433
• Identity: 136/433 - (31%)
• Similarity: 228/433 - (52%)
• Gaps: 36/433 - (8%)

  Fly    11 EDEEQTETTA------------VENQ---EAPKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCG 60
            |:||:.:..|            |:|.   |..::|......|:.|  |.:..|||::|:.:...|
Mouse    48 EEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPSSPLYSVKS--FEELRLKPQLLQGVYAMG 110

  Fly    61 FEHPSEVQHECIPQ--AVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELA 123
            |..||::|...:|.  |....:::.|::||.||||.||||.|.::||:|... ..|.:..|.|||
Mouse   111 FNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPADRYP-QCLCLSPTYELA 174

  Fly   124 FQISKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKK-LNLKLL 187
            .|..|..|:..|:.|.:|:|....|..:::.::.    :..||:||||.:|......| ::.|.:
Mouse   175 LQTGKVIEQMGKFHPELKLAYAVRGNKLERGQKV----SEQIVIGTPGTVLDWCSKLKFIDPKKI 235

  Fly   188 KHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEA 252
            |.|||||.|.|:.....:.....|.|..|...|:::||||....:....:|.:.||..:.:..|.
Mouse   236 KVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNIIKLKREE 300

  Fly   253 KLTLHGLQQHYV--NLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIH 315
            : ||..::|:||  |.:| ||.:.|..|...:...|.:||..:.:....|:..|:::......:.
Mouse   301 E-TLDTIKQYYVLCNNRE-EKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLS 363

  Fly   316 RGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSD------TYLHRVAR 374
            ..|..|:|....::|::.::::||.||:..||:|:|:|::|.|:|:|.|.|      |||||:.|
Mouse   364 GEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGR 428

  Fly   375 AGRFGTKGLAITFVSDENDAKILNEVQDRFDVNISEL-PEEID 416
            .||||.:|||:..|..::...|||.:|:.|:..|..| .:::|
Mouse   429 TGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLD 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	69/210 (33%)
		SF2_C_DEAD	259..388	CDD:350174	46/136 (34%)
Ddx19a	NP_031942.2	N-terminal lobe. /evidence=ECO:0000250	2..299		78/257 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..53		3/4 (75%)
		N-terminal helix. /evidence=ECO:0000250	54..67		1/12 (8%)
		DEAD-like_helicase_N	74..302	CDD:475120	73/235 (31%)
		Q motif	91..119		10/29 (34%)
		DEAD box	241..244		2/2 (100%)
		C-terminal lobe. /evidence=ECO:0000250	300..478		57/174 (33%)
		SF2_C_DEAD	306..442	CDD:350174	46/136 (34%)