Protein Alignment Hel25E and DDX19B

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001350867.1
• Gene: DDX19B / 11269
• HGNCID: 2742
• Length: 484
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 136/432 - (31%)
• Similarity: 225/432 - (52%)
• Gaps: 35/432 - (8%)

  Fly    12 DEEQTETTAVE---------------NQ-EAPKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCG 60
            |||:.|..|.:               || |..::|......|:.|  |.:..|||::|:.:...|
Human    54 DEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKS--FEELRLKPQLLQGVYAMG 116

  Fly    61 FEHPSEVQHECIP--QAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELA 123
            |..||::|...:|  .|....:::.|::||.||||.||||.|.|:||: |.....|.:..|.|||
Human   117 FNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPA-NKYPQCLCLSPTYELA 180

  Fly   124 FQISKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKK-LNLKLL 187
            .|..|..|:..|:.|.:|:|....|..:::.::.    :..||:||||.:|......| ::.|.:
Human   181 LQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKI----SEQIVIGTPGTVLDWCSKLKFIDPKKI 241

  Fly   188 KHFVLDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEA 252
            |.|||||.|.|:.....:.....|.|..|...|:::||||....:....:|.:.||..:.:..|.
Human   242 KVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE 306

  Fly   253 KLTLHGLQQHYVNL-KENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIHR 316
            : ||..::|:||.. ..:||.:.|..|...:...|.:||..:.:....|:..|:::......:..
Human   307 E-TLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSG 370

  Fly   317 GMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSD------TYLHRVARA 375
            .|..|:|....::|::.::::||.||:..||:|:|:|::|.|:|:|.|.|      |||||:.|.
Human   371 EMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRT 435

  Fly   376 GRFGTKGLAITFVSDENDAKILNEVQDRFDVNISEL-PEEID 416
            ||||.:|||:..|..::...|||.:|:.|:..|..| .:::|
Human   436 GRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLD 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	70/210 (33%)
		SF2_C_DEAD	259..388	CDD:350174	44/135 (33%)
DDX19B	NP_001350867.1	DEAD-like_helicase_N	80..308	CDD:475120	76/235 (32%)
		SF2_C_DEAD	312..448	CDD:350174	44/135 (33%)