Protein Alignment Hel25E and DDX39A

DIOPT Version :10

• Sequence 1: NP_723089.1
• Gene: Hel25E / 33781
• FlyBaseID: FBgn0014189
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_005795.2
• Gene: DDX39A / 10212
• HGNCID: 17821
• Length: 427
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 352/425 - (82%)
• Similarity: 390/425 - (91%)
• Gaps: 4/425 - (0%)

  Fly     1 MADND---DLLDYEDEEQTETTAVENQEAPKKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCGFE 62
            ||:.|   |||||::||:.:.........||||:||:|||||||||||||||||:||||||||||
Human     1 MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFE 65

  Fly    63 HPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELAFQIS 127
            |||||||||||||:||||:|||||||||||||||||||||:||. |....|||||||||||||||
Human    66 HPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPV-NGQVTVLVMCHTRELAFQIS 129

  Fly   128 KEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKKLNLKLLKHFVL 192
            |||||||||||:|||:|||||::|:||||.||...||:|||||||||||:||:..:||.:|||||
Human   130 KEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVL 194

  Fly   193 DECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEAKLTLH 257
            |||||||||||||||||||||.|||.||.|||||||||||||||:|||||||||:||||.|||||
Human   195 DECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLH 259

  Fly   258 GLQQHYVNLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIHRGMTQEE 322
            ||||:||.||::|||:|||:||||||||||:|||||||||:||:|||.|||||||.|||||.|||
Human   260 GLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEE 324

  Fly   323 RLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITF 387
            ||:|||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   325 RLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITF 389

  Fly   388 VSDENDAKILNEVQDRFDVNISELPEEIDLSTYIE 422
            |||||||||||:|||||:||::|||||||:|||||
Human   390 VSDENDAKILNDVQDRFEVNVAELPEEIDISTYIE 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	176/207 (85%)
		SF2_C_DEAD	259..388	CDD:350174	114/128 (89%)
DDX39A	NP_005795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		13/32 (41%)
		DEADc_DDX39	43..250	CDD:350708	176/207 (85%)
		Q motif	44..72		26/27 (96%)
		DECD box	195..198		2/2 (100%)
		SF2_C_DEAD	261..390	CDD:350174	114/128 (89%)