Protein Alignment Cap-D3 and YCS4

DIOPT Version :10

• Sequence 1: NP_608935.2
• Gene: Cap-D3 / 33778
• FlyBaseID: FBgn0051989
• Length: 1267
• Species: Drosophila melanogaster
• Sequence 2: NP_013374.1
• Gene: YCS4 / 850977
• SGDID: S000004262
• Length: 1176
• Species: Saccharomyces cerevisiae
• Alignment Length: 1256
• Identity: 235/1256 - (18%)
• Similarity: 446/1256 - (35%)
• Gaps: 401/1256 - (31%)

  Fly    59 ETQLQLLRDLSAIIRAMRDENQASYSNTHDNWSNLIGFSP-------ALGYLTYIYSLVSLVVLP 116
            :|||..|  :|:.:..:..:.:|:.| ::.|::.:.|..|       ..|||..    |.|..|.
Yeast    70 QTQLSYL--ISSSLSNLSKDIKANLS-SNVNFTEIGGLIPQWKRHLEEYGYLIQ----VLLTFLQ 127

  Fly   117 EHVQQAAPQQLNENINMQLALNAATTYLLTLTIPGAKIFGVFDEDV--IEQVLK-VFRLLEMNNN 178
            :.:.:.:.|..|.|.:.:.:.|.:....|            |..|.  :|.:|: :.:|||:|.:
Yeast   128 DELHKVSSQSTNLNRSAKNSKNDSANVEL------------FKRDCNQMENLLESITKLLEINLS 180

  Fly   179 KSLRASMIWMFFLTICDDLKIVFRYVHFKEHLKTRDRIIRCLLEV----LYMNFKMGYQNTCAPG 239
            |        :|..|...||.|         .|.||...:  |||:    ...:.||..|...|..
Yeast   181 K--------IFQTTPEKDLFI---------GLFTRPLFV--LLEIEPVTKVSSLKMFIQRILAMC 226

  Fly   240 L--HGKCFELFSEIANEHNGDVYETLHLIMRQTFPMHVYTDS---PQMI-------------AYG 286
            :  ||:...:.|.:..    ::...|||.:.....:.:..|.   ||:.             |..
Yeast   227 VKNHGQSSSIQSSLMT----NLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNAKD 287

  Fly   287 RRGAMQSGEHISDWFIQLIDKYPDIVNRILHFYIECVVSNPIKAWKSNDEKVAIGYAAKYDRVLF 351
            ..|.    :.||::.|:|.:..|.|:.|.::..|..:          |:..:.:
Yeast   288 TTGP----KAISNFLIKLSELSPGIMLRQMNLVITLL----------NNSSITL----------- 327

  Fly   352 TKCN--KSCADYV---------LEAVKADDAVGIQI--------------RALDLIEKILLQESE 391
             :|:  ::|.:.|         :|..|...||.|::              :|:....||....|:
Yeast   328 -RCSVVEACGNIVAELAQDPQTMEHYKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKICDLSSK 391

  Fly   392 VEWSIFRHEVSDVPREVPLLREVLRCLNDRTLTVRRKACQVLILALRQ-------GSPM------ 443
            ...|           :.......:|.|.||:..|||.:.::|...|.:       ||.:
Yeast   392 FNKS-----------KAKFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKHPFKAIHGSQLRLSEWE 445

  Fly   444 -----TKKILQESIRFVQ----FDDTDVEALAEPSAQQNE--LRFEKPGIVQYAFSFQGHEQL-- 495
                 ::..|..:::.|:    .:||...:|.|...:|:|  .|.|..|      ||....:|
Yeast   446 EYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEG------SFNKSAELSR 504

  Fly   496 -ETEVKNLPQTVYQRFLAADNGLARSAGIALLERLVLVNPLIIY---NTNFVKE--TSLLAVDRL 554
             |.||:|:..|                ..::|.:|.|   :|:|   ..:|:||  .|:..:..|
Yeast   505 IENEVENINAT----------------NTSVLMKLKL---MIVYYKDAISFIKEIHKSIELISNL 550

  Fly   555 --SSVRKSALETIE--TLLEAYS---NCFALICVYCRIWACLMSDEDVALQKLAISSFDRMVLKN 612
              |..|...||:::  .|.:|:.   :.|.:..:...:|....:||..::....|..:.::.|..
Yeast   551 LFSKNRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTA 615

  Fly   613 IQPLEYSNEAKHFMPWRI-ISTLLMTQPRAYLQERFAVLLERETIVTPRLVNVIIS-HLSTSMAT 675
            ........:|.|.....| :|........|.|::...::.|:: ::...::|::.: :.|.|.|:
Yeast   616 PDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQK-LIDQHVINILWAIYNSASKAS 679

  Fly   676 ----------DA---------------WGLLLFLSSRIT-NNMDALIGIFNGLSSYNMKS----- 709
                      |:               .|:|....:.|. ..:::|:.|  ||.:..:|.
Yeast   680 MQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNI--GLGAVGLKDLTLCR 742

  Fly   710 NQFLALQ--------LITGCL-RNFSKPALNQLFQKLLNALRTGSIW---------LGIISSAVN 756
            ...|||:        :||..: :.....|:.:|:..::|..:....:         |..|||..:
Yeast   743 YSCLALERMVPKRSTIITKAINQELEDVAVKKLYAIIINYTKDNEYYPMCEQALSALFTISSKPD 807

  Fly   757 LL-----------------NQIHHLSTSQSPTIASEMPYWQLSLLEDLVEGI----LSSAQNFQE 800
            :|                 .:...||..||..:.|      ||.|..:|..:    |...:..:.
Yeast   808 ILATDLIREKTMMTFGKPEEEDSILSLEQSSRVVS------LSQLLFIVGQVAIKTLVYLEKCEA 866

  Fly   801 EYAR-------------------------------LQCLLGA----YTELIVMVPQDVDNRIVSI 830
            |:.:                               |:.:.|.    :|:.|..|.::      .:
Yeast   867 EFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKEN------EL 925

  Fly   831 VFKYLQECTKLCE--SEFDSDNERMTNWMIVIAGRLSLR-----DNHLANSASKLYITILTKNDR 888
            :|.......|.|.  .|..|::.|.::.|:.....|.|.     .:.....:..|.||::.|:..
Yeast   926 LFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPD 990

  Fly   889 PQIINTTLIALNDLGKKHPSILESNFQAILSKLQSKFAMTRVRTFRCVKDVILSGNIKLKGPILI 953
            |.|.:..::.|.|:.....::::.|...:..:|..:..|.:......|..:||:|.:|:||.:
Yeast   991 PTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQL-- 1053

  Fly   954 SMLAALVDESAEVAREADAFFTRYKKLYNKMLFDHCLKECPFDLNDQAILRGVRTNGNYKSPLKG 1018
                      .|:|:                    ||     |..||.|....|        |..
Yeast  1054 ----------GEMAK--------------------CL-----DNPDQGISDMCR--------LFF 1075

  Fly  1019 SQMAKKRRLLYN---HIMSSMDENVLLLYFGQ------LKLL---AEKTRDQAFINNPDALI--- 1068
            :::|.|...:||   .|.|::..:.||   |:      :|.|   .:|.|.|..:|  :.|:
Yeast  1076 TELASKDNAIYNGFIDIFSNLSSDDLL---GKESFKKIIKFLLTFIDKERHQKQLN--EKLVGRL 1135

  Fly  1069 -------VVQDMLFIMRRICY 1082
                   ...|:.|::..:.|
Yeast  1136 RKCETQKQWDDIAFVLNNLPY 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D3	NP_608935.2	COG5098	<829..984	CDD:227429	29/161 (18%)
YCS4	NP_013374.1	COG5098	1..1171	CDD:227429	235/1256 (19%)
		HEAT repeat	313..342	CDD:293787	5/50 (10%)
		HEAT repeat	351..384	CDD:293787	5/32 (16%)
		HEAT repeat	943..965	CDD:293787	5/21 (24%)
		HEAT repeat	977..1006	CDD:293787	8/28 (29%)