Protein Alignment Cap-D3 and Ncapd3

DIOPT Version :10

• Sequence 1: NP_608935.2
• Gene: Cap-D3 / 33778
• FlyBaseID: FBgn0051989
• Length: 1267
• Species: Drosophila melanogaster
• Sequence 2: NP_835214.2
• Gene: Ncapd3 / 78658
• MGIID: 2142989
• Length: 1506
• Species: Mus musculus
• Alignment Length: 1425
• Identity: 259/1425 - (18%)
• Similarity: 489/1425 - (34%)
• Gaps: 426/1425 - (29%)

  Fly   106 IYSLVS--LVVLPEHVQQAAPQQLNENINMQLALNAATTYLLTLTIPGAKIFGVFDEDVIEQVLK 168
            |::|:.  |.:||:...:..||.:...|.:.:||.:                       .|.:..
Mouse   217 IFNLLKNFLRLLPKFSLKEKPQSIQTCIEVFVALTS-----------------------FEPIPH 258

  Fly   169 VFRLLEMNNNKSLR--ASMIWMFFLTICDDLKIVFRYVHFKEHLKTRDRIIRCLLEVLYMNFKMG 231
            .|.:.:..|...::  :.:.:.....:|..       ||.:|: |....|...:|.|:.| .::|
Mouse   259 KFLISQARNLNEVKHISELAYYGLYLLCSP-------VHGEEN-KVIGSIFHQMLNVILM-LEVG 314

  Fly   232 YQNTCAP--------GLHGKCFELFSEIANEHNGDVYETLHLIMRQTFPMHVYTDSPQMIAYGRR 288
            ..:.|||        ....:..:..|.:.:|....||..|..:::     |:.........| |.
Mouse   315 EGSRCAPLAITSQVINCRNQAVQFVSSLVDELQASVYPVLGTLLQ-----HICAKVVDKAEY-RT 373

  Fly   289 GAMQSGEHISDWFIQLIDKYPDIVNRILHFYIECVVSNPIKAWKSNDEKVAIGYAAKYDRV---- 349
            .|.||       .:||:.|.|                       |.:....|.:..||.|.
Mouse   374 YAAQS-------LVQLLTKLP-----------------------SEEYATFIAWLYKYSRSSKIP 408

  Fly   350 --LFTKCNKSCADYVLEAVKADDAVGIQIRALDLIEKILLQESEVEWSIFRHEVSDVPREVPLLR 412
              :|| .:.:.|...|...:.||.|.::      .:|.|..:..|:..||.
Mouse   409 HRVFT-LDVALALLTLPERELDDTVSLE------HQKFLKHKFFVQEIIFD-------------- 452

  Fly   413 EVLRCLNDRTLTVRRKACQVLILALRQGSPMTKKILQESIRFVQFDDTDVEALAEPSAQQNELRF 477
               ||| |:..|||.||.......|...|..|    .|||..:..:...|..:...|   |.:..
Mouse   453 ---RCL-DKAPTVRSKALSSFAHCLELSSSNT----SESILEIFINSNLVPGIQNLS---NTVLN 506

  Fly   478 EKPGIVQ---YAFSFQGHEQLETEVKNLP-----QTVYQRFLAADNGLARSAGIALLERLVLVNP 534
            ..|.:..   |:...:.|...|   :.||     .|:.::.:..:....|.:.:.:|
Mouse   507 PSPVLTSRNGYSAQSRTHNNDE---QTLPGERCFMTMLRKRIKDEKINVRKSALQVL-------- 560

  Fly   535 LIIYNTNFVKETSLLAV------------DRLSSVRKSALETIETLLEAYSNCFALICVYCRIWA 587
                 .:.:|...:|::            |...||||.||:::..|:.|...|..:    .:.|.
Mouse   561 -----MSILKHCDILSMEQDLLILQDHCRDPAISVRKQALQSLTELVMAQPTCVPV----QKAWL 616

  Fly   588 C----LMSDEDVALQKLAISSFDRMVLKNIQPLE--YSNEAKHFMPWRIISTLLMTQP--RAYLQ 644
            .    ::.|.:..:|:.|:...|:::|:||:..:  :|.:....:.|.:::.|.:...  |.||.
Mouse   617 MGVIPVVMDCESTVQEKALECLDQLLLQNIKHHKKFHSADRSQVLAWSLLALLTIENQDLRRYLN 681

  Fly   645 ERFAVLLERETIVTPRLVNVIISHLSTSMATDAWGLLLFLSSRITNNMDAL-----IGIFNGLSS 704
            :.|.:..:::.. :...:|.:|||..|..:..||.||    |:||.:...|     |..:..||.
Mouse   682 KAFHIWSKKDKF-SSTFINSVISHTDTERSAPAWMLL----SKITCSSPKLDYTKIIESWERLSR 741

  Fly   705 YNMKSNQFLALQL-ITGCLRNFSKPALNQLFQKLLNALRTGSIWL-GIISSAVNLLNQIHHLSTS 767
            ....::..|...| :.|.:..............::.|...|..|. .:|||:|:.|.:   |..:
Mouse   742 EQSPNSNTLGYMLCVIGHIAKHLPKGTRDKITGVIKAKLNGFQWSPELISSSVDALQK---LCRA 803

  Fly   768 QSPTIASEMPYWQLSLLEDLVEGILSSAQNF-------------QEEYARLQCL--LGAYTELIV 817
            .:.|:..|.     .||:.:...:|::.:..             .:|...::|:  ||   ::..
Mouse   804 SAKTVLEEQ-----GLLKQVCGDVLATCEQHLSNILLKEDGTGNMDEGLVVKCIFTLG---DIAQ 860

  Fly   818 MVPQDVDNRIVSIVFKYL------------QECTKLCESE--FDSDNERMTNWM----IVIAGRL 864
            :.|..|:.|:..::...|            |..|...:|:  |...:..|.:.:    |:..|:|
Mouse   861 LCPAIVEKRVFLLIQSILASSAHSDHLPSSQGTTDALDSQPPFQPRSSAMPSVIRAHAIITLGKL 925

  Fly   865 SLRDNHLANSASKLYITILTKNDRPQIINTTLIALNDLGKKHPSILESNFQAILSKLQSKFAMTR 929
            .|:...||..:....:..|..::...:.|..:|.:.||..::..::::....|...|:......|
Mouse   926 CLQHEDLAKKSIPALVRELEVSEDVAVRNNVIIVICDLCIRYTVMVDNYIPNISVCLKDSDPFIR 990

  Fly   930 VRTFRCVKDVILSGNIKLKGPILISMLAALVDESAEVA-------------READAF-------- 973
            .:|...:.:::....:|.||.:....::.|||...::|             |....|
Mouse   991 KQTLVLLTNLLQEEYVKWKGSLFFRFVSTLVDSHPDIASLGEFCLAHLLLKRNPTMFFQHFIECI 1055

  Fly   974 --FTRYKK--LYN---------------------------KMLFDHCLKECPFDLNDQAILR--G 1005
              |..|:|  .||                           |.|.:|...|..|::..:..|.  .
Mouse  1056 FHFNSYEKHGQYNKFSQSERGKQLFLLKGKTNKEKRMRIYKFLLEHFTDEQRFNVTSKICLNILA 1120

  Fly  1006 VRTNGNYKSPLKGSQM---------AKKRRLLYNHIMSSMD----ENVLL----LYFGQLKLLAE 1053
            ..|:|.....::.|::         :|:.:||.....:|.|    ::|.|    :...|:|::::
Mouse  1121 CFTDGILPMDMEASELLSDTFDILNSKEIKLLAMRAQTSKDLLEEDDVALANVVMQEAQMKIISQ 1185

  Fly  1054 KTRDQAFINNPDALIV-------------VQDMLFIMRRIC----------------------YC 1083
             .:.:.||.|...:|:             :::::..:|.:.                      |.
Mouse  1186 -VQKRNFIENIIPIIISLKTVLEKNKIPALRELMNYLREVMQDYRDEINDFFAVDKQLASELEYD 1249

  Fly  1084 TKGMGK---EKNSRGEGDNIDEG-EDASSEP--------------------ATPPTRPEAGEATS 1124
            .|...:   ::.:..|..|..:| ||:...|                    |.....|.|..|.:
Mouse  1250 MKKYNEQLAQEQALTEHANATKGPEDSDRVPSAQVAPDLEAVPALAAAPMAAAAAAAPMAAAAAA 1314

  Fly  1125 RGRGRKADMSEEPLKQLERCLRFVEETHRNIVPVMSPELSHN----FESFCRAMAMRFPNYIEFA 1185
            .|:    |.::.|..|..     ......|..|.: |.:|.|    ..|..|.|::.....:
Mouse  1315 AGQ----DNADVPPTQSR-----PSAPRSNFTPTL-PPISENGPLKIMSSTRPMSLSTIAIL--- 1366

  Fly  1186 QPAQFWRQFRSSAKAPRASRSKRR-------RMEEGEVESHEEHES----ESDSDSELPLDRHKT 1239
                      :|.|...||:::.|       .:|.|..|:...|||    |.:||..:   .|.|
Mouse  1367 ----------NSVKKAVASKNRTRSLGALPFNVETGSPENPSSHESSLSLEKESDRTV---NHVT 1418

  Fly  1240 ------------------------TP----TASRLSQRKTSCDMLVTELIF----QPPDW 1267
                                    ||    |..:...::...|:|...|:.    |.|.|
Mouse  1419 KRAISTPENSISDVTFAAGVSYIGTPATFFTKEKHEAQEQGSDILCLSLLDKRPPQSPQW 1478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D3	NP_608935.2	COG5098	<829..984	CDD:227429	35/224 (16%)
Ncapd3	NP_835214.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..194
		HEAT 1	442..476		13/51 (25%)
		HEAT repeat	483..524	CDD:293787	7/43 (16%)
		HEAT 2	532..567		5/47 (11%)
		VHS_ENTH_ANTH	<538..603	CDD:470608	13/77 (17%)
		HEAT repeat	538..566	CDD:293787	3/40 (8%)
		HEAT 3	574..605		8/30 (27%)
		HEAT repeat	575..600	CDD:293787	7/24 (29%)
		HEAT repeat	611..641	CDD:293787	5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	884..908		4/23 (17%)
		HEAT repeat	936..965	CDD:293787	5/28 (18%)
		Cnd1	951..1127	CDD:463677	30/175 (17%)
		HEAT 4	968..1004		4/35 (11%)
		HEAT repeat	973..1000	CDD:293787	4/26 (15%)
		HEAT repeat	1011..1037	CDD:293787	4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1317..1353		8/45 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1385..1412		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1473..1506		3/6 (50%)