Protein Alignment Cap-D3 and ncapd3

DIOPT Version :9

• Sequence 1: NP_001162887.1
• Gene: Cap-D3 / 33778
• FlyBaseID: FBgn0051989
• Length: 1267
• Species: Drosophila melanogaster
• Sequence 2: NP_956624.1
• Gene: ncapd3 / 556493
• ZFINID: ZDB-GENE-040426-737
• Length: 1419
• Species: Danio rerio
• Alignment Length: 1510
• Identity: 267/1510 - (17%)
• Similarity: 489/1510 - (32%)
• Gaps: 491/1510 - (32%)

  Fly    79 NQASYSNTHDNW----SNLIGFSPALGYLTYIYSLVSLVVLPEHVQQAAPQQLNENINMQLALNA 139
            |:...:||.:.|    .|.:.....:..|:|.       :|....:..:.:|      ....|.|
Zfish    61 NEDDDNNTENVWVVFGENGVSAKTLVAVLSYF-------ILSAKTKSPSLEQ------RLCGLQA 112

  Fly   140 ATTYLLTLTIPGAKIFGVFDEDVIEQVLKV-FRLLEMNNNK-----SLRASMIWMFFLTICDDLK 198
            |:.|||.|.|||:....|:.:.:.:..|.: .:.....:.|     ||::|.         .|.|
Zfish   113 ASLYLLLLKIPGSVANKVYHQILFDTCLNMPLKCWPQESGKKRKKDSLKSSQ---------GDPK 168

  Fly   199 IVFR------------------------YVHFKEHLKTRDRI---IRCLLEVLYMNFKMGYQNTC 236
            ...|                        |...::.||.|:.|   :|.||.:| ..|.:..:
Zfish   169 TGKRSKPPKKVSEEMEIDDDEEDEDEGMYFSAQDLLKLREGIVLLVRTLLRLL-ERFSLRDK--- 229

  Fly   237 APGLHGKCFELFSEIAN------------EHNGD--------VYETLHLI-----------MRQT 270
             |.....|.:||:|:.|            |.|.|        .|..|.|:           .|:.
Zfish   230 -PQSADSCVQLFTELTNFEPVIGDLSFSQERNVDQLQSLPELSYHGLGLLCSTVHGEGDECRRRV 293

  Fly   271 FPMHVYT---------DSPQMIAYGRRGAMQSGEHISDWFI-QLIDKYPD--------IVNRILH 317
            |...:|.         ..|.::|..:  |:......:..|| .::|:..:        :|..|.|
Zfish   294 FRKLLYVILMMKTQERSRPSLLAPSQ--AVCGARDQAILFISHIVDEQREATLPLLRILVQHICH 356

  Fly   318 FYIECVVSNPIKAWKSNDEKVAIGYAAKYDRVLFTKCNKSCADYV-----LEAVKADDAVGIQIR 377
            ..:|   .:..:|..|.    |:|       .|..|  ..|.||.     |.....::.|..::.
Zfish   357 QMVE---KSEYRASGSQ----AVG-------KLMAK--MPCQDYAATIKWLYNYSRNNKVAFRMF 405

  Fly   378 ALDLIEKILLQESE--------VEWSIF---RHEVSDVPREVPLLREVLRCLNDRTLTVRRKACQ 431
            ||| :..:||:::|        .|.::|   |..|.::         |....||.:.|||..|..
Zfish   406 ALD-VSMVLLEQTERDVDDTVDPELAVFLSHRFLVHNI---------VYNHRNDVSPTVRGHALH 460

  Fly   432 VLILALRQGSPMTKKILQESIRFVQFDDTDVEALAEPSAQQNELRFEKPGIVQYAFSFQ-----G 491
            .|...|..||....|.:.|..      ......:.|....:..|:..:.| .:.|.:|:     .
Zfish   461 CLAQCLELGSQNATKCVHELF------SNSAHTMMESDRSEQTLKRRETG-QKTALTFRTIELTK 518

  Fly   492 HEQLETEVKNLPQTVYQRFLAADNGLARSAGIALLERLVLVNPLIIYNTNFVKETSLLAVDRLSS 556
            |:.:.|..:::..|..|.    |..:                      |.|.|..|    |..::
Zfish   519 HKSMTTTHRSVMNTSLQN----DESM----------------------TLFKKHVS----DPKTN 553

  Fly   557 VRKSALETIETLLE------AYSNCFALICVYCRIWA---------CLMS--------------- 591
            .|||||||:.:||:      :..| .:::...||..|         |||.
Zfish   554 ARKSALETVMSLLKHGVIACSLEN-LSMLSDRCRDPAVSVKKKALQCLMELLNALPDNKDVQEAW 617

  Fly   592 ---------DEDVALQKLAISSFDRMVLKNIQPLEYSNEAKH------FMPWRIISTLLMTQP-- 639
                     |.:.::|:.|:...|..::.:|:    |::..|      .:.|.::.  ||.:.
Zfish   618 LRGVLPAVMDSESSVQEKALECMDHAIIAHIK----SHKKNHNINVSQKLAWDLLG--LMCEKCQ 676

  Fly   640 --RAYLQERFAVLLERETIVTPRLVNVIISHLSTSMATDAWGLLLFLSS-----RITNNMDALIG 697
              ..|..:.|:|...::.. ||..||.::||.....|:.||.||..::|     .....:|....
Zfish   677 DLSRYFSKAFSVWAPQQKF-TPAFVNNLLSHTEGERASAAWLLLAKVASCSPKLNYGTVLDTWEN 740

  Fly   698 IFNG-LSSYNMKSNQFLALQLITGCLRNFSKPALNQLFQKLLNALRTGSIWLGIISSAVNLLNQI 761
            |... :.|..|..:   .|.::.....|.:....:::...|:..|:|.|:...:|||.|:.|.:.
Zfish   741 IIRAPVVSVTMTCH---ILSVMGDIAFNINDDTKSRIVDDLMGWLKTFSLPSEVISSCVDALVRF 802

  Fly   762 HHLSTSQS-----PTIASEMPYWQLSLLEDLVEGIL---SSAQNFQEE----------YARLQCL 808
            .....:|.     .....|:    :::.|..:..:|   ...:|..|:          .|.|.|
Zfish   803 GRSDDTQETLRFMDRFCGEL----VAVCEKYLSSVLLQEKGTENINEDLLVKHLYTLGVASLHC- 862

  Fly   809 LGAYTELIVMVPQDVDNRIVSIVFKYLQECTKLCESEFDS--DNERMTNW------------MIV 859
                       |..|..||..:|...|........:|.|.  .::.::.:            .::
Zfish   863 -----------PSKVGKRIFLLVQSILTPLEHPVSAEGDGLPASQPLSQFKPTSMPTVVRAHAVI 916

  Fly   860 IAGRLSLRDNHLANSASKLYITILTKNDRPQIINTTLIALNDLGKKHPSILESNFQAILSKLQSK 924
            ..|:|.|:...|......::...|.......:.:..::.:.||..::.:.:......|.:.|:.:
Zfish   917 TLGKLCLQHEDLMMKYLPVFARELEVGTELAVRSNVVVVMCDLCVRYTNTVTRYIPNISACLRDE 981

  Fly   925 FAMTRVRTFRCVKDVILSGNIKLKGPILISMLAALVDESAEVAREADAFFTRYKKLYNKMLFDHC 989
            ..:.|.:|...:.:::....:|.|||:.......|||....:|...:..........:.::|...
Zfish   982 EPIVREQTLIMLTNLLQEEYVKWKGPLFFRFAVVLVDPDPAIADLCEYCLVDLLLKKSPLMFSQH 1046

  Fly   990 LKECPFDLND-------QAILRGVRTNGNYKSPLKGSQMAKKRRLLYN------------HIMSS 1035
            ..||.|..|.       ....:..|....:.  |||.|...:|..:|.            :|.|.
Zfish  1047 FIECIFHFNSYEKHKKYNKFTQTEREKSRFS--LKGPQNQGRRFRIYRFLLKNFTDEQRFNITSK 1109

  Fly  1036 MDENVL-----------------------LLYFGQLKL--------------------------- 1050
            :.::||                       :|...::||
Zfish  1110 ICQDVLASFVDSELPLDSEGSELLADTFDILSLKEMKLTAMSGPAAGEEAQEDEMALAKAVLQVA 1174

  Fly  1051 ---LAEKTRDQAFINNPDALIV------------------------VQDM------LF-----IM 1077
               |..:.:.:.|:.|...:|:                        :||.      ||     :.
Zfish  1175 QKKLVSQVQKRNFVENVIPIIISLKNMLEEQHSPVLKHLMAYLQVTMQDYRSEVKELFAADEQLA 1239

  Fly  1078 RRICYCTKGMGKEKNSRGEGD----------NIDEGEDASSEPATPPT----RPEAGEAT----- 1123
            ..:.|..|...|:|..:.:..          :..:.|:|.:.||....    .|:.|.||
Zfish  1240 AEVEYNLKQFEKQKQQQEQLQMENQLANFTMSPRQNENAVASPAQAANGGRQTPKGGFATPLNRH 1304

  Fly  1124 -SRGRGRKADMSEEPLKQLERCLRFVEETHRNIVPVMSPELSHNFESFCRAMAMRFPNYIEFAQP 1187
             ::|.| :...|.:||::            |....:::|..||                   ..|
Zfish  1305 ANKGPG-QTPKSADPLRR------------RTYAGIVTPVRSH-------------------LSP 1337

  Fly  1188 AQF----WRQFRSSAKAPRASRSK-------------RRRMEEGEVESHEEHESESDSDSELPLD 1235
            ..|    .:|...:...|:||.::             .||:.:||.|.:..|....:....:|..
Zfish  1338 TVFSTGRGKQVGRAISTPQASINEVTFGEQVSAICNDSRRVSKGEEEENVLHLMSPEQKKPVPRQ 1402

  Fly  1236 RHKTTPTASRLSQRK 1250
            .:..:|...:...:|
Zfish  1403 WNVESPLVQKQRAKK 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D3	NP_001162887.1	Cnd1	889..>999	CDD:289487	18/109 (17%)
ncapd3	NP_956624.1	HEAT repeat	538..568	CDD:293787	14/55 (25%)
		HEAT repeat	577..602	CDD:293787	6/25 (24%)
		HEAT repeat	613..640	CDD:293787	3/26 (12%)
		Cnd1	948..1144	CDD:289487	31/197 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0413
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39493at33208
OrthoFinder	1	1.000	-	-		FOG0006480
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14222
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.900