Protein Alignment Cap-D3 and Ncapd3

DIOPT Version :10

• Sequence 1: NP_608935.2
• Gene: Cap-D3 / 33778
• FlyBaseID: FBgn0051989
• Length: 1267
• Species: Drosophila melanogaster
• Sequence 2: XP_006242797.1
• Gene: Ncapd3 / 315508
• RGDID: 1562176
• Length: 1497
• Species: Rattus norvegicus
• Alignment Length: 1460
• Identity: 257/1460 - (17%)
• Similarity: 480/1460 - (32%)
• Gaps: 484/1460 - (33%)

  Fly    41 RAEKFWTMAMCLQDGGHQETQLQL-LRDLSAIIRAMRDENQASYSNTHDNWSNLIGFSPALGYLT 104
            |.|.:....:..::...:|.::.. :||||.|    ||.
  Rat   186 RKEDYQVDELSREEEEEEEEEIYFSVRDLSQI----RDA-------------------------- 220

  Fly   105 YIYSLVS--LVVLPEHVQQAAPQQLNENINMQLALNAATTYLLTLTIPGAKIFGVFDEDVIEQVL 167
             |::|:.  |.:||:...:..||.:...|.:.:||.:                       .|.:.
  Rat   221 -IFNLLKNFLRLLPKFSLKEKPQSIQTCIEVFVALTS-----------------------FEPIP 261

  Fly   168 KVFRLLEMNNNKSLR--ASMIWMFFLTICDDLKIVFRYVHFKEHLKTRDRIIRCLLEVLYMNFKM 230
            ..|.:.:..|...::  :.:.:.....:|..       || .|..|....|...:|.|:.| .::
  Rat   262 HKFLISQARNLSEVKHISELAYYGLYLLCSP-------VH-GEGNKVIGSIFHQMLNVILM-LEV 317

  Fly   231 GYQNTCAP--------GLHGKCFELFSEIANEHNGDVYETLHLIMRQTFPMHVYTDSPQMIAYGR 287
            |..:.|||        ....:..:..|.:.:|....|:..|..:::     |:.........| |
  Rat   318 GEGSRCAPLAITSHVINCRNQAVQFVSSLVDELQESVFPILGTLLQ-----HICAKVVDKAEY-R 376

  Fly   288 RGAMQSGEHISDWFIQLIDKYPDIVNRILHFYIECVVSNPIKAWKSNDEKVAIGYAAKYDRV--- 349
            ..|.||       .:||:.|.|                       |.:....|.:..||.|.
  Rat   377 TYAAQS-------LVQLLSKLP-----------------------SKEYATFIAWLYKYSRSSKI 411

  Fly   350 ---LFTKCNKSCADYVLEAVKADDAVGIQIRALDLIEKILLQESEVEWSIFRHEVSDVPREVPLL 411
               :||      .|..|..::..:      |.||  :.:||:..:    ..:|:.        .:
  Rat   412 PHRVFT------LDVALALLELPE------RLLD--DTVLLEHQK----FLKHKF--------FV 450

  Fly   412 REVL--RCLNDRTLTVRRKA----CQVLILALRQGSPMTKKIL---------------------- 448
            :|::  ||| |:..|||.||    .|.|.|:....|..|.:|.
  Rat   451 QEIIFDRCL-DKAPTVRSKALSSFAQCLELSTSNTSENTLEIFINSTVTGIHSHFGTSLRPSTVL 514

  Fly   449 -QESIRFVQFDDTDVEALAEPSAQQNELRFEKPGIVQYAFSFQGHEQLETEVKNLPQTVYQRFLA 512
             .:|.|.||....|.:....|..::              |.....::.:.|..|:.::..|..::
  Rat   515 TSQSCRSVQSSTHDSDEQTPPGERR--------------FMTMLRKRTKDEKINVRKSALQVLMS 565

  Fly   513 ADNGLARSAGIALLERLVLV------NPLIIYNTNFVKETSLLAVDRLSSVRKSALETIETLLEA 571
                :.:...|..:|..:|:      :|.|                   ||||.||:::..|:.|
  Rat   566 ----ILKHCDILSMEEDLLILQDHCRDPAI-------------------SVRKQALQSLTELVMA 607

  Fly   572 YSNCFALICVYCRIWAC----LMSDEDVALQKLAISSFDRMVLKNIQPLE--YSNEAKHFMPWRI 630
            ...|..:    .:.|..    ::.|.:..:|:.|:...|:::|:||:...  :|.:....:.|.:
  Rat   608 KPTCVPV----QKAWLMGVIPVVMDYESTVQEKALECLDQLLLQNIKHHRKFHSEDRSQVLAWAL 668

  Fly   631 ISTLLMTQP--RAYLQERFAVLLERETIVTPRLVNVIISHLSTSMATDAWGLLLFLSSRIT---- 689
            ::.|.:...  ..||.:.|.:..:::.. :...:|.:|||..|..:..||.||    |:||
  Rat   669 LALLTVESQDLSRYLNKAFHIWSKKDKF-SSTFINSVISHTDTERSAPAWMLL----SKITCSSP 728

  Fly   690 ----------------------NNMDALIGIFNGLSSYNMKSNQFLALQLITGCLRNFSKPALNQ 732
                                  |.:..::.:...::.:..||.|    ..|||.:    |..||
  Rat   729 KLDYTKIMESWEKLSREQSPNSNTLGYMLCVIGHIAKHLPKSTQ----DKITGVI----KAKLN- 784

  Fly   733 LFQKLLNALRTGSIW-LGIISSAVNLLNQIHHLSTSQSPTIASEMPYWQLSLLEDLVEGILSSAQ 796
                       |..| |.:||.:|:.|   ..|..:.:.|:..|.     .||:.:...:||:.:
  Rat   785 -----------GFQWSLELISLSVDTL---QGLCRASAKTLREEQ-----ELLKRVCGDVLSTCE 830

  Fly   797 --------------NFQEEYARLQCL--LGAYTELIVMVPQDVDNRIVSIVFKYL---------- 835
                          |..|:.. ::|:  ||   ::..:.|..|:.|:..::...|
  Rat   831 QHLSNILLKEDGTGNMDEDLV-VKCIFTLG---DIAQLCPALVEKRVFLLIQSILASSAHADHLP 891

  Fly   836 --QECTKLC-ESEFDSDNERMTNWM----IVIAGRLSLRDNHLANSASKLYITILTKNDRPQIIN 893
              |..|.|. :..|.:.:..:.:.:    |:..|:|.|:...||..:....:..|...:...:.|
  Rat   892 SSQGTTDLASQLPFQARSSALPSVIRAHAIITLGKLCLQHEDLAKKSIPALVRELEVCEDVAVRN 956

  Fly   894 TTLIALNDLGKKHPSILESNFQAILSKLQSKFAMTRVRTFRCVKDVILSGNIKLKGPILISMLAA 958
            ..:|.:.||..::..::::....|...|:......|.:|...:.:::....:|.||.:....::.
  Rat   957 NVIIVMCDLCIRYTVMVDNYIPNISICLKDSDPFIRKQTLILLTNLLQEEYVKWKGSLFFRFVST 1021

  Fly   959 LVDESAEVAREADAFFTRYKKLYN-KMLFDHCLKECPFDLNDQAILRGVRTNGNYK--------S 1014
            |||...::|...:..........| .|.|.|.: ||.|..|      ....:|.|.        .
  Rat  1022 LVDSHPDIASLGEFCLAHLLLKRNPTMFFQHFI-ECIFHFN------SYEKHGQYNKFSQSERGK 1079

  Fly  1015 P---LKGSQMAKKRRLLYNHIMSSM-DE-----------NVL----------------------- 1041
            |   |||....:||..:|..::... ||           |:|
  Rat  1080 PLFLLKGKTNKEKRMRIYKFLLEHFTDEQRFNVTSKICLNILACFTDGVLPVDMEASELLSDTFD 1144

  Fly  1042 LLYFGQLKLLA------------------------------EKTRDQAFINNPDALIV------- 1069
            :|...::||||                              .:.:.:.||.|...:|:
  Rat  1145 ILSSKEIKLLAMRAQASKELLEEDDVALANVVMQEAQMKIISQVQKRNFIENIIPIIISLKTVLE 1209

  Fly  1070 ------------------------VQDMLFIMRRIC---------YCTKGMGKEK--NSRGEGDN 1099
                                    ::|...:.|::.         | |:.:.:|:  .......|
  Rat  1210 KNKIPALRELMNYLREVMQDYRDEIKDFFAVDRQLASELEYDMKKY-TEQLAQEQALTEHANATN 1273

  Fly  1100 ID-EGEDASSEPATPPTRPEAGEATSRGRGRKADMSEEPLKQLERCLRFVEETHRNIVPVMSPEL 1163
            :. :|:...|:...|..:...|.|.:.|.|:.......||.|.:     ......:..|.:.|
  Rat  1274 VPADGDRVPSQQVAPDLQAVPGAAAAAGAGQADANMPLPLAQSQ-----PSAPGSSFTPTLPP-- 1331

  Fly  1164 SHNFESFCRAMAMRFPNYIEFAQPAQFWR-QFRSSAKAPRASRSKRR-------RMEEGEVESHE 1220
                  .|....::.   :...:|..... ...:|.|...||:|:.|       .||.|..|:..
  Rat  1332 ------ICEKGPLKI---MSSTRPMSLSTIAILNSVKKAVASKSRTRSLGALSFNMENGSPENPS 1387

  Fly  1221 EH------ESESDSDSELPLDRHKTTPTAS 1244
            ..      |.||:...:....|..:||..|
  Rat  1388 SRASSLSLEQESERAVKRVTKRAISTPEKS 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D3	NP_608935.2	COG5098	<829..984	CDD:227429	28/172 (16%)
Ncapd3	XP_006242797.1	PDS5	<457..>604	CDD:410996	36/184 (20%)
		HEAT repeat	486..569	CDD:410996	12/100 (12%)
		HEAT repeat	541..569	CDD:293787	3/31 (10%)
		HEAT repeat	578..603	CDD:293787	9/43 (21%)
		HEAT repeat	579..604	CDD:410996	9/43 (21%)
		HEAT repeat	614..644	CDD:293787	5/33 (15%)
		Cnd1	953..1129	CDD:463677	36/182 (20%)