Protein Alignment Cap-D3 and hcp-6

DIOPT Version :10

• Sequence 1: NP_608935.2
• Gene: Cap-D3 / 33778
• FlyBaseID: FBgn0051989
• Length: 1267
• Species: Drosophila melanogaster
• Sequence 2: NP_491537.1
• Gene: hcp-6 / 266830
• WormBaseID: WBGene00001833
• Length: 1758
• Species: Caenorhabditis elegans
• Alignment Length: 1388
• Identity: 254/1388 - (18%)
• Similarity: 504/1388 - (36%)
• Gaps: 359/1388 - (25%)

  Fly   134 QLALNAATTYLLTLTIPGAKIFGVFDEDVIE----------QVLKVFRLLEMNN---NKSLRASM 185
            ::|:::|..||..||   .::|.....:...          :|::....|:::|   .:::||:.
 Worm   203 RIAVDSAERYLHHLT---TQLFAFLHSNTFSIDTPTLMSTLEVVEDIGRLDLDNRTAGRAIRANS 264

  Fly   186 IWMF-FLTICDDLKIVFRYVHFKEHLKTR-----DRIIRCLLEVLYMNFKMGYQNTCAPGLHGKC 244
            :..| .|....|....|.:...:...|||     .|:||..|.:      |.|     |....|.
 Worm   265 VHEFRSLERFTDRYCAFVHSLVESKYKTRAEVAYGRLIRPRLAL------MPY-----PDESNKS 318

  Fly   245 FELFSEIANEHNGDVYETLHL--IMR----------QTFPMHVYTDSPQMIAYGRRGAMQSGEHI 297
            .::.:|  .:.:|:::..|.|  |.|          ||..:.||:..|.:..:        ..:|
 Worm   319 SKISTE--RKRSGELHVNLILSRISRNPEARELKYIQTVTVMVYSQCPDLAEF--------RTNI 373

  Fly   298 SDWFIQLIDKYP-----DIVNRILHFYIECVVSNPIKAWKSNDEKVAIGYAAKYDRVLFTKCNKS 357
            :.:..::::..|     |.|.     ::..:........||...:::....:.:|   ||..:..
 Worm   374 ATFIHKILEALPYTYTYDFVQ-----FMNVLFKGRGAGVKSLSTELSSILISSFD---FTAPDPG 430

  Fly   358 C------------------ADYVLEAVKADDAVGIQIRAL----------DLIEKILLQESEVEW 394
            .                  .|...|.....|.|.::....          |..|.:..::.|.:.
 Worm   431 AIPNLDAEQNEEEDEEEEGEDEEEEEENEQDDVAVKEEEQSDKSDEENDGDNEENVSKKKEEKKK 495

  Fly   395 SIFRHEVSDVPR--EVPLLREV--LRCLNDRTLTVR----------------RKACQVLILALRQ 439
            .....||.:|.|  .:.:|..:  :.|| |:...:|                |:|.|:....:
 Worm   496 EKKAKEVKEVGRMDAMSVLYNIVYMACL-DKAAAMRLHGANSLTKILQSQSHREAFQLFCATI-- 557

  Fly   440 GSPMTKKI------LQESIRFVQFDDTDVEALAEPSA---QQNELRFEKPGIVQYAFSFQGHEQL 495
            .:.|.:|.      |.||:     :|.:|...| ||:   :..:|..::..|:|.....:...:.
 Worm   558 NAEMDEKFGAVGDNLSESL-----EDLNVSGKA-PSSKTKKPTDLLLDEQQIIQKFNKLKLMNKG 616

  Fly   496 ETEV-KNLPQTVYQRFLAADNGLARSAGIALLERLVLVNPLIIYNTNFVKETS----------LL 549
            ||.| |::...:.:|....|....:.|..:||:..:          ::..|.|          :|
 Worm   617 ETRVEKDIVYMIVRRLSTDDKAPVKKAACSLLKSYL----------SYCDEASKFEVVLSILQML 671

  Fly   550 AVDRLSSVRKSALETIETLLEAYSNCF--ALICVYCRIWACLMSDEDVALQKLAISSFDRMVLKN 612
            ..||:.||||:..:....|:...:..|  :|...:......:::|.|..:.:.|    .::::|.
 Worm   672 CRDRMVSVRKTGADAFTELMLRDAILFKESLSSKWLHTLISMLNDTDNDVTEHA----RKLIMKV 732

  Fly   613 IQP-LEYSNEAKHFMPWRIISTL-LMTQPRAYLQE--RFAVLLERETIVTPRLVNVIISH-LSTS 672
            :.| ||.|::    :.|.::.|: .:|..|.||..  :.||   ||.:|...:::.:..| :|.|
 Worm   733 LTPLLENSSD----LTWTLLDTIESVTNHRQYLMSTLKDAV---REKLVKRTVMDSMKQHIISGS 790

  Fly   673 MATD-AWGLLLFLSSRITNNMDALIGIFNGLSSYNMKSN--QFLALQLITGCLRNFSKPALNQLF 734
            ...| ||.:...|..:...|:|..|..|:.: ..:.:||  |:: :.:|...::.......:.|.
 Worm   791 EKLDGAWMVFSQLCVQFEQNVDFAIETFSRV-DLSRESNLVQYM-IHVIENNIKKIDDDTKSDLV 853

  Fly   735 QKLLNALR--------TGSIW--LGIISSAVNLLNQIHHLSTSQSPTIASEMPYWQLSLLEDLVE 789
            ..|....|        :.||:  ||.:...:. ...:|          ..|...:..:||....:
 Worm   854 NTLQGTFRDYCLHPSHSRSIYHCLGKLMDGIG-DRSLH----------GKEFSDFGETLLIKCFD 907

  Fly   790 GILSSAQNFQ---------EEYARLQC-LLGAYTELIVMVPQDVD-----NRIVSIVFK------ 833
            .|:.|.:.|:         |...||.| .|...:|:....||.|.     .:.:|::..
 Worm   908 TIVQSFEMFKDKDEWKRNSESQERLLCTALNVASEVFSYSPQLVPRHERLGKTLSLIVNSTENGS 972

  Fly   834 --------------YLQECTKLCE---SEFDSDNERMTNW------MIVIAGRLSLRDNHLANSA 875
                          :.:..|:|.|   |:..|....|::.      .:...|.::|.:..||:..
 Worm   973 SDASTVNPDMPSVHHTRPPTQLSEVPSSQKSSKGGMMSHEGAMFSDKVRAVGVVTLANMILAHDR 1037

  Fly   876 SKLYITILTK----NDRPQIINTTLIALNDLGKKHPSILESNFQAILSKLQSKFAMTRVRTFRCV 936
            ....:.:|.|    |...||.:..::|:.|:...:.:  :.....:.:.|.....:.|......:
 Worm  1038 LLKLMPMLVKQLQYNTAHQIRSNIVLAIGDICSSYKT--DRYAPMLAASLCDPSVIVRRHAINQI 1100

  Fly   937 KDVILSGNIKLKGPILISMLAALVDESAEVAREADAFFTRYKKLYNKMLFDHCLKECPFDLNDQA 1001
            ..:|..|..:..|.|:|.|:.|.:|.:.:|..:|..:.:...:......|.....:....|....
 Worm  1101 ARLISFGIFRFNGEIMIRMMLASLDANEDVRNDAKLYISEVLQSEEPNFFPLNFVQYMIALTQAR 1165

  Fly  1002 ILRGVRTNGNYKSPLK-----GSQMAKKRRL-LYNHIMSSMDENV---LLLYFGQLKLLAEKTRD 1057
            .|.||..:.:.:..:.     |..:|:..|: :|..::.|:|:..   :.:...| ::.......
 Worm  1166 RLVGVGHDEDDRGQVDVAIGGGDPLARPSRIAIYTFMIDSLDDRSRFDVKMSICQ-RIFTPIVNG 1229

  Fly  1058 QAFINNPDALIVVQDMLFIMRRICYCTK-GMGKEKNSRGEGDNIDEGEDASSEPATPPTRPEAGE 1121
            :...::.:...::.|.|.||.......| .:||..|           |:|..:|:     ||..|
 Worm  1230 EYDFSDYNVQCLLDDALLIMASNEMQVKMDVGKNPN-----------ENAMDDPS-----PEVLE 1278

  Fly  1122 ATSRGRGRKA--------------------DMSEEPLKQLERCL---RFVEETHRNIVPVM---- 1159
            |.: |..:|.                    :....||::  :||   |.:...|:|.:..:
 Worm  1279 AAT-GFMQKVYLDHYMKTIVPSILSLREFLNQHRSPLQR--KCLLAIRMICIEHKNDIDEILQDN 1340

  Fly  1160 -----------------SPELSHNFESFCRAMA---------MRFPNYIEF-AQPAQFWRQFRSS 1197
                             :.|.:...:.:.:.:|         .:.|..:|. |:|.|      .|
 Worm  1341 RQLKDEMMFELQRVKQRTEEANRILDEYLKRVAEFKKQQKRLSKSPAPMELDAEPVQ------ES 1399

  Fly  1198 AKAPRASRSKRRRMEEGEVESHEEHE----SESDSDSELP---------LDRHKTTPTASRLSQ- 1248
            |:|.... |..||:||.:....||.|    .:.:.|:::|         ....|:||.|..||.
 Worm  1400 AEAVEMG-SPARRIEEDQENVEEEVEMRTPQKKNPDADVPRTPLNALRSTTEEKSTPNARLLSPK 1463

  Fly  1249 -----RKTSCDMLVTELIFQPPD 1266
                 |::...::.||:...||:
 Worm  1464 TIKKIRRSLGALIHTEMRLNPPN 1486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-D3	NP_608935.2	COG5098	<829..984	CDD:227429	30/187 (16%)
hcp-6	NP_491537.1	HEAT repeat	629..653	CDD:293787	5/33 (15%)
		HEAT repeat	663..696	CDD:293787	8/32 (25%)
		HEAT repeat	1041..1070	CDD:293787	7/28 (25%)
		Cnd1	1057..>1153	CDD:463677	16/97 (16%)
		HEAT repeat	1079..1106	CDD:293787	3/26 (12%)
		HEAT repeat	1115..1140	CDD:293787	7/24 (29%)