DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Coq6 and COQ6

DIOPT Version :9

Sequence 1:	NP_608934.1	Gene:	Coq6 / 33777	FlyBaseID:	FBgn0031713	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_872282.1	Gene:	COQ6 / 51004	HGNCID:	20233	Length:	468	Species:	Homo sapiens

Alignment Length:	480	Identity:	201/480 - (41%)
Similarity:	270/480 - (56%)	Gaps:	44/480 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ARLLS----VRLLASKSTTDMTTNRGESTQSTSTEHFDIIIGGGGLVGTTLAAALAKNSTLADKK 77
            |||:|    ||  |:..:..:.:.|..|..||.|. :|:::.||||||..:|.||..:....|||
Human     3 ARLVSRCGAVR--AAPHSGPLVSWRRWSGASTDTV-YDVVVSGGGLVGAAMACALGYDIHFHDKK 64

  Fly    78 VLLLEGAPEFRGFNPTGPYQNRVSAINHNSIELFKSIDAWKHIESARYKPVKQMQVWESNTDALI 142
            :||||..|:......:..|.||||:|:..|..|..|..||.||.:.||:..::||||::.::|||
Human    65 ILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQVWDACSEALI 129

  Fly   143 QFQHDNFASDVACIIENDLILDAVYALAKE----SPNVEILNKARIQCVR------LPRDSNSNH 197
            .|..||. .|:..|:|||:|:   :||.|:    |..|.:|.:::  .:|      .|...:|..
Human   130 MFDKDNL-DDMGYIVENDVIM---HALTKQLEAVSDRVTVLYRSK--AIRYTWPCPFPMADSSPW 188

  Fly   198 SELQLEDGRNFSCDLLIGADGANSVVRKEMNVDVFSLNYDRMGLVATLELGEDACDNSVAWQRFL 262
            ..:.|.||..|...|||||||.||.||:.:.:...|.|||:..:||||.|.| |.:|:|||||||
Human   189 VHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSE-ATENNVAWQRFL 252

  Fly   263 PNGPVALLPLTDRLSSLVWSTTNEQAKMLQALPPTEFVDALNEAFCRQYPRVELADKAVQALNSL 327
            |:||:|||||:|.||||||||::|.|..|.::...:||||:|.||.......:..|.|...|
Human   253 PSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAML--- 314

  Fly   328 FGHNGSQHQV-----------QYPPRVCGVLDKSRATFPLGFLHASSYVCNGAALVGDAAHRVHP 381
                  |:.|           |.||.|..|..|||..||||..||:.||....||:|||||||||
Human   315 ------QYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHP 373

  Fly   382 LAGQGVNLGFSDVRYLVESLAAGAYAGFKLGDKQHLIKYERKCLAKNVPIMLGVHGLHTLYATQF 446
            |||||||:||.|:..|...|:..|:.|..||...||..||.:....|..::.....|..||:|..
Human   374 LAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSA 438

  Fly   447 SPVVLLRSLGLQLTQNLPPVKNLFM 471
            ||:||||:.|||.|..:.|:|...|
Human   439 SPLVLLRTWGLQATNAVSPLKEQIM 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq6	NP_608934.1	Ubi-OHases	58..476	CDD:273913	185/435 (43%)
Coq6	NP_608934.1	COQ6	58..471	CDD:273914	184/433 (42%)
COQ6	NP_872282.1	Ubi-OHases	48..467	CDD:273913	182/432 (42%)
COQ6	NP_872282.1	COQ6	48..463	CDD:273914	181/430 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154127
Domainoid	1	1.000	55	1.000	Domainoid score	I11203
eggNOG	1	0.900	-	-		E1_COG0654
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6039
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2581
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54916
OrthoDB	1	1.010	-	-		D418762at33208
OrthoFinder	1	1.000	-	-		FOG0003239
OrthoInspector	1	1.000	-	-		oto89926
orthoMCL	1	0.900	-	-		OOG6_102655
Panther	1	1.100	-	-	LDO	PTHR43876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R236
SonicParanoid	1	1.000	-	-		X1881
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800