DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Coq6 and coq6

DIOPT Version :9

Sequence 1:	NP_608934.1	Gene:	Coq6 / 33777	FlyBaseID:	FBgn0031713	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_595401.2	Gene:	coq6 / 2539672	PomBaseID:	SPBC146.12	Length:	479	Species:	Schizosaccharomyces pombe

Alignment Length:	490	Identity:	154/490 - (31%)
Similarity:	217/490 - (44%)	Gaps:	56/490 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSVRLLASKSTTDMTT--------NRGESTQSTSTEHFDIIIGGGGLVGTTLAAALAKNSTLADK 76
            :|..:|...|..:|.|        .|..::|......||::|.|.|.||..|||.|..|......
pombe     1 MSSLVLRGVSRVEMPTISPTLGIYTRKFASQKILQRQFDVVIVGSGPVGLALAAGLQSNPVTQSL 65

  Fly    77 KVLLLEGAPEFR----GFNPTGPYQNRVSAINHNSIELFKSIDAWKHIESARYKPVKQMQVWESN 137
            ||.||:.....:    .|.   .|.||.|::.:::...|..|.||......|.:|.:.:...:..
pombe    66 KVGLLDIQDTMKLKDWKFE---TYSNRCSSLTNHTRMFFDKIGAWDFARKDRIQPFQHILASDGL 127

  Fly   138 TDALIQFQHDNFASDVACIIENDLILDAVYALAK----------ESPNVEILNKARIQCVRLPRD 192
            |::.|.......:..:|.:.||   ::..|||..          :.||:|.|....|  .:|.:.
pombe   128 TNSSIHLDQKPGSEPMAFMSEN---VNLQYALLNSIIDKMNNNIKKPNLEFLMPCTI--TKLSKG 187

  Fly   193 SNSNHSELQLEDGRNFSCDLLIGADGANSVVRKEMNVDVFSLNYDRMGLVATLELGEDACDNSVA 257
            .|...:.:........:..|||||||.||:|||..|:.:...||....:|.||:: :.....:||
pombe   188 ENIYRTHIHTTTHGELTTKLLIGADGRNSIVRKYANISMPGWNYLTHAVVGTLKI-DPLKGPAVA 251

  Fly   258 WQRFLPNGPVALLPLTDRLSSLVWSTTNEQAKMLQALPPTEFVDALNEAFCRQYPRV-------- 314
            :|||||.||:|.|||.|..::.||||....|..|..||...||..||.:|...||.:
pombe   252 FQRFLPTGPLAYLPLPDNNATFVWSTRPHIASKLLRLPEETFVKFLNASFRLDYPDLSYLYQMDF 316

  Fly   315 -------ELADKAVQALNSLFGHNGSQHQVQYPPRVCGVLDKSRATFPLGFLHASSYVCNGAALV 372
                   |..|..:|...:        ..:|.||.:..::..|||.|||...|...||..|.||.
pombe   317 SEPSKVNEQLDWRLQVKRN--------SNMQVPPVITEIVSGSRAAFPLRLAHVDEYVKEGIALC 373

  Fly   373 GDAAHRVHPLAGQGVNLGFSDVRYLVESLAAGAYAGFKLGDKQHLIKYERKCLAKNVPIMLG-VH 436
            |||||..|||||||:|.|..||..|:.:|:.....|..:|....|..|.|....|| .:.|| |.
pombe   374 GDAAHNTHPLAGQGLNTGIQDVESLISALSFAIKHGQDIGSVFSLQPYFRDRYFKN-HVYLGVVD 437

  Fly   437 GLHTLYATQFSPVVLLRSLGLQLTQNLPPVKNLFM 471
            ..|.|||.:...|..:|:|||.|......:||..:
pombe   438 KFHKLYAMENPVVTSVRTLGLSLFDRSASLKNFIL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq6	NP_608934.1	Ubi-OHases	58..476	CDD:273913	142/444 (32%)
Coq6	NP_608934.1	COQ6	58..471	CDD:273914	142/442 (32%)
coq6	NP_595401.2	COQ6	38..472	CDD:273914	147/451 (33%)
coq6	NP_595401.2	Ubi-OHases	39..474	CDD:273913	146/452 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	115	1.000	Domainoid score	I1525
eggNOG	1	0.900	-	-		E1_COG0654
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6039
Inparanoid	1	1.050	192	1.000	Inparanoid score	I1042
OMA	1	1.010	-	-		QHG54916
OrthoFinder	1	1.000	-	-		FOG0003239
OrthoInspector	1	1.000	-	-		oto101223
orthoMCL	1	0.900	-	-		OOG6_102655
Panther	1	1.100	-	-	LDO	PTHR43876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R236
SonicParanoid	1	1.000	-	-		X1881
TreeFam	1	0.960	-	-
	14	13.860