Protein Alignment Vps52 and VPS52

DIOPT Version :9

• Sequence 1: NP_608931.1
• Gene: Vps52 / 33774
• FlyBaseID: FBgn0031710
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_010772.1
• Gene: VPS52 / 852095
• SGDID: S000002892
• Length: 641
• Species: Saccharomyces cerevisiae
• Alignment Length: 672
• Identity: 139/672 - (20%)
• Similarity: 267/672 - (39%)
• Gaps: 130/672 - (19%)

  Fly    18 VREILKNTTD----LRQYSRQIEKE-------------FKEVENKSIEDYIAESQNIANLHNQIN 65
            ::|:|....|    |::.||....|             ||...||. :...|:.:::...|:. |
Yeast     4 LKEVLSLDQDKFDQLKETSRDKTNETDDPFENYLKDCKFKAPSNKD-QSPFAKLKSLQETHSN-N 66

  Fly    66 DC--DDVLERMENMLMSFQSVLNNISTEITQLQRKSVSMSLQLTNRQSVKAQLSQFIEDMAVSEE 128
            :.  :.::.::.:.|..|.:.|:|.:.::..:::||..:...|....:..|.:|..:.|:.:..|
Yeast    67 EAAINIIIPQLIDYLTEFTNRLSNYTQDLDFIKKKSNELQSLLEYNSTKLAHISPMVNDLMIPPE 131

  Fly   129 MINIIMETPVTE-----------------RDFSTQLNVLNHKLSLVKELSFKESKSTSDVSDVLQ 176
            :|:.|::..:.|                 :..|..|:..|........|:.|:......:.|:|:
Yeast   132 LIDDIIKGKINESWQDNITFIADKEEIYNKYRSNNLDQDNKDAENSAMLAPKDFDKLCQLLDILK 196

  Fly   177 KLRLKAMAKIRSYLLEQIYKFR--KPMTNYQIPQNAMLKHKFFFEFILSNERHVAQEICSEYIDT 239
            .:.|:...::   ::.:|...|  .|:.:.:| ||.:||.:..|.||..|...:|.|:...|..|
Yeast   197 NVILERSKRL---IISKIKTLRSHNPVPSQRI-QNKLLKVQKIFPFIRDNNLSLALELRQAYCYT 257

  Fly   240 MGKIYYSYFKSYSTRLTSLKFEE---------SCTKDDLMGIED------------NASKGLFSK 283
            |...|..||..|...||.|:|::         ..:...:.|..:            :||...::|
Yeast   258 MKWYYREYFSRYIRSLTILQFQQIDSQFALGNGLSTTSVSGFNNSPSLFFSNYLTTSASNAFYNK 322

  Fly   284 TTSLKHK-STIFTIGKRGDILNQQLEAPIIVPHAQLKNRYTA----EALFRSEQYALVDNACREY 343
            ......| ...|.|.||.:||.|:....::   :|:....|.    |..|::...|::||...||
Yeast   323 LPVTDEKIDKYFQIKKRLNILTQEDNTVMV---SQIAENNTTKNYIEIGFKNLNLAILDNCTVEY 384

  Fly   344 LFVTEFFMVRGTQAQD---LFNQIMGKTLTLMIKNLETSIHDCFDTIAMFLCIHLIFRYQLMCHK 405
            .|:.:||.:.|...::   |..||...|........:..|...:|...:.:.|.:..:.|....:
Yeast   385 HFLKDFFAMNGDNFEEINGLLEQIFQPTFDEATTYTQQLIQYNYDIFGVLISIRVANQLQFESER 449

  Fly   406 RCVPAL-DKYWDSLQAVIWPRFELVFRLNIQSIHDCD-PTKFNKELG------------PHYITR 456
            |.:|:: |.:.:.....:||||:.:.....:|:.... .|...|..|            ||.:|.
Yeast   450 RGIPSMFDSFLNGQLIQLWPRFQQLVDFQCESLRKAAITTNVAKYAGNSSTSNSSPLTSPHELTV 514

  Fly   457 RYAEFSAAIV--------GISEHFPNELVSRLLLELQNEVECFILRMA--AIFPTR--KDQLIYL 509
            ::.:|.::.:        .|.|.  :|.:...::.|:|:.|..:.:.:  ...|.|  ....:||
Yeast   515 QFGKFLSSFLTLAITHKQSIDER--SEPLYNSIIRLRNDFETVMTKCSKKTKSPERFLATNYMYL 577

  Fly   510 INNYDLVLGVLMEHTRDNSKEAEAFREQLNSRSAEYVEEILA---PHFGGIIQFVKECEHFFEKE 571
            .||    |..|..|...|..:|:.:    |..|||.|...:|   .:...:...::|.|:.|:
Yeast   578 YNN----LQQLHLHLNINDSDAQNY----NFDSAENVGTKVANDDDNDSSVPLIIRETENHFK-- 632

  Fly   572 QMDELRKQERRSLALVASFSAN 593
                         .||.:|:.|
Yeast   633 -------------TLVEAFTRN 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps52	NP_608931.1	Vps52	42..546	CDD:282044	121/579 (21%)
VPS52	NP_010772.1	Sec3_C	47..607	CDD:418729	121/578 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341319
Domainoid	1	1.000	84	1.000	Domainoid score	I1917
eggNOG	1	0.900	-	-		E1_KOG1961
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1584
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54348
OrthoFinder	1	1.000	-	-		FOG0003722
OrthoInspector	1	1.000	-	-		oto100043
orthoMCL	1	0.900	-	-		OOG6_101848
Panther	1	1.100	-	-	LDO	PTHR14190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1656
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830