DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps52 and Vps52

DIOPT Version :9

Sequence 1:	NP_608931.1	Gene:	Vps52 / 33774	FlyBaseID:	FBgn0031710	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_008770928.1	Gene:	Vps52 / 25218	RGDID:	3618	Length:	753	Species:	Rattus norvegicus

Alignment Length:	690	Identity:	335/690 - (48%)
Similarity:	486/690 - (70%)	Gaps:	41/690 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDNEEVREILKNTTDLRQYSRQIEKEFKEVENKSIEDYIAESQNIANLHNQINDCDDVLERMENM 77
            |::|.|:|.||...|||.||:|:|.|.:::|.|||.|||.||:|||:|||||..||.||||||.|
  Rat    65 LEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQM 129

  Fly    78 LMSFQSVLNNISTEITQLQRKSVSMSLQLTNRQSVKAQLSQFIEDMAVSEEMINIIMETPVTERD 142
            |.:|||.|::||.||..||.:|.:|:::|.|||:|:.:|.:.::.:.|...::..|:|.||||..
  Rat   130 LGAFQSDLSSISCEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPR 194

  Fly   143 FSTQLNVLNHKLSLVKELSFKESKSTSDVSDVLQKLRLKAMAKIRSYLLEQIYKFRKPMTNYQIP 207
            |..||..|:.|.:.|:|...:.:.:.:||..||.:||:||:.|||.::|::||.|||||||||||
  Rat   195 FLEQLQELDAKAAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIP 259

  Fly   208 QNAMLKHKFFFEFILSNERHVAQEICSEYIDTMGKIYYSYFKSYSTRLTSLKFEESCTKDDLMGI 272
            |.|:||::||::|:|.|||..|:|:..||::|:.|||.||::||..||..:::||...||||||:
  Rat   260 QTALLKYRFFYQFLLGNERATAKEVRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGV 324

  Fly   273 EDNASKGLFSKTTSLKHKSTIFTIGKRGDILN-QQLEAPIIVPHAQLK--NRYTAEALFRSEQYA 334
            ||.|.||.||| .||:.::||||:|.||.::: .:|||||:|||...:  .||..||||||:.||
  Rat   325 EDTAKKGFFSK-PSLRSRNTIFTLGTRGAVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYA 388

  Fly   335 LVDNACREYLFVTEFFMVRGTQAQDLFNQIMGKTLTLMI-----------------KNLETSIHD 382
            |:||:||||||:.|||:|.|..|.|||:.:||:||::.:                 |:||:.:.|
  Rat   389 LLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLPLEQQLTFSCLPVAVPQKHLESYLAD 453

  Fly   383 CFDTIAMFLCIHLIFRYQLMCHKRCVPALDKYWDSLQAVIWPRFELVFRLNIQSIHDCDPTKF-N 446
            |:|.||:|||||::.|::.:..||.|||||:||:.:.|::||||||:..:|:||:...||.:. .
  Rat   454 CYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGG 518

  Fly   447 KELGPHYITRRYAEFSAAIVGISEHFPNELVSRLLLELQNEVECFILRMAAIFPTRKDQLIYLIN 511
            .:..||||||||||||:|:|.|::..|||...:||.:||.|||.|:||:||.|.:||:||::|||
  Rat   519 LDTRPHYITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLIN 583

  Fly   512 NYDLVLGVLMEHTRDNSKEAEAFREQLNSRSAEYVEEILAPHFGGIIQFVKECEHFFEKEQMDEL 576
            |||::||||||...|:|||.|:|::.||:|:.|::||:|:|.|||::.||||.|...|:.|.:.|
  Rat   584 NYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERL 648

  Fly   577 RKQERRSLALVASFSANWKKSLEELNREVLLSFPSLLTGSQLL-------------QLALASLVQ 628
            |.:|.|...|:..|.::||.|:|.|:::|:.||.:...|:.::             |.||..|:|
  Rat   649 RGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLTPLCSVQGALTQLIQ 713

  Fly   629 YYHRFHKLLT-PN-----ARAQLTNIHVVMVEIKKYKSNY 662
            .|||||::|: |.     |||:|.|||.:|||:||:|.|:
  Rat   714 LYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps52	NP_608931.1	Vps52	42..546	CDD:282044	266/524 (51%)
Vps52	XP_008770928.1	Vps52	94..618	CDD:282044	277/544 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334381
Domainoid	1	1.000	548	1.000	Domainoid score	I247
eggNOG	1	0.900	-	-		E1_KOG1961
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5756
Inparanoid	1	1.050	683	1.000	Inparanoid score	I684
OMA	1	1.010	-	-		QHG54348
OrthoDB	1	1.010	-	-		D139156at33208
OrthoFinder	1	1.000	-	-		FOG0003722
OrthoInspector	1	1.000	-	-		oto98080
orthoMCL	1	0.900	-	-		OOG6_101848
Panther	1	1.100	-	-	LDO	PTHR14190
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3644
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770