Protein Alignment Vps52 and vps-52

DIOPT Version :9

• Sequence 1: NP_608931.1
• Gene: Vps52 / 33774
• FlyBaseID: FBgn0031710
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_509282.4
• Gene: vps-52 / 181018
• WormBaseID: WBGene00007059
• Length: 702
• Species: Caenorhabditis elegans
• Alignment Length: 672
• Identity: 233/672 - (34%)
• Similarity: 404/672 - (60%)
• Gaps: 26/672 - (3%)

  Fly    14 DNEEVREILKNTTDLRQYSRQIEKEFKEVENKSIEDYIAESQNIANLHNQINDCDDVLERMENML 78
            |...|::.:.:...|.:....:.....|....|::..:..|:.:|.||||:..||:|.||::..|
 Worm    34 DPNLVKKAIASGDGLTESKNDVSTRLSEAHRYSVQQCLDNSEQLAQLHNQLVHCDNVFERLQATL 98

  Fly    79 MSFQSVLNNISTEITQLQRKSVSMSLQLTNRQSVKAQLSQFIEDMAVSEEMINIIMETPVTERDF 143
            .|||..|.:|..::..||.:|..:..:|.|||.|:.:||||::|:|||:.|:..|.:|...:|.|
 Worm    99 YSFQDNLGSIGQDMKNLQLQSHHIHQELENRQKVRVELSQFVDDIAVSQTMMKTINDTDANDRGF 163

  Fly   144 STQLNVLNHKLSLVKELSFKESKSTSDVSDVLQKLRLKAMAKIRSYLLEQIYKFRKPMTNYQIPQ 208
            ...|:.|:||::|:.:....::.:.:|...:|:.|:|||:.|:|.:||:::::||||::|||:.|
 Worm   164 LEALHELHHKITLILQRGNGDAVAVNDTMPILEGLKLKAVVKVREWLLQKMFQFRKPLSNYQVFQ 228

  Fly   209 NAMLKHKFFFEFILSNERHVAQEICSEYIDTMGKIYYSYFKSYSTRLTSLKFEESCTKDDLMGIE 273
            :.:||.:||:||:|.::...|:|:..|||||:.|::::|||:|:|||..|..::..||:|.:|..
 Worm   229 HQLLKCRFFYEFLLHHDLISAKELQDEYIDTISKMFFTYFKAYATRLFKLAMKDVATKEDALGSI 293

  Fly   274 DNAS-KGL----FSKTTSLKHKSTIFTIGKRGDILNQQLEAPIIVPHAQLKNR--YTAEALFRSE 331
            |.|. .||    .||...:::|:|:|:||:|..||:......:|||||..:|.  |..||||||.
 Worm   294 DFAKPAGLGAIFSSKQHVVRNKATVFSIGQRHQILSDDFLGALIVPHAATQNHQSYQFEALFRSI 358

  Fly   332 QYALVDNACREYLFVTEFFMVRGTQAQDLFNQIMGKTLTLMIKNLETSIHDCFDTIAMFLCIHLI 396
            |.|.||:...||||:|:||:|...:|.:|.|:.|.:.:::::|:.|..|...:|.|::.|||.|.
 Worm   359 QLAFVDHYSHEYLFITDFFLVSNDEAIELHNKAMARAMSVVLKSCEEQIALSWDAISLHLCICLC 423

  Fly   397 FRYQLMCHKRCVPALDKYWDSLQAVIWPRFELVFRLNIQSIHDCDPTKF----NKELGPHYITRR 457
            .::..:..:|.||.:..||:::.:.:|.|..||...:.:|:...|..|.    :.:..||:|.||
 Worm   424 DKFTEVLAEREVPEVSDYWNTVTSFLWTRLNLVMSQHYESVKSVDLKKLMHSGSLDARPHFIVRR 488

  Fly   458 YAEFSAAIVGISEHFPNELVSRLLLELQN---EVECFILRMAAIFPTRKDQLIYLINNYDLVLGV 519
            |||.::|.:.|::....|:.:::...|:|   .:|..:.||:|:..|:|::.::|||||||:|.:
 Worm   489 YAELTSAHLMIAKASGKEMGAKMEAVLENSEDSIEQLLTRMSAMQQTQKNKHVFLINNYDLILSI 553

  Fly   520 LMEHTRDNSKEAE--AFREQLNSRSA-EYVEEILAPHFGGIIQFVKECEHFFEKEQMDELRKQER 581
            :   ..:.||..:  |...:|..:|. ::|||:|.||.|.:|:||.|||....:.....|.:...
 Worm   554 I---DNEESKHTKIYAIVHELEQKSIDDFVEEMLEPHIGYMIKFVNECESLIVQGHTQLLVRYND 615

  Fly   582 RSLALVASFSANWKKSLEELNREVLLSFPSLLTGSQLLQLALASLVQYYHRFHKLLTPNARA--- 643
            :...:||:|:|.|:.:::.:|.|.:..|.:...|:.:||......|||.:||.|:|:.:..|
 Worm   616 KVGTVVANFNAKWRPAVDSINSECIQLFTNFSLGTTILQTIFTKYVQYINRFTKILSHDVFAKNP 680

  Fly   644 ---QLTNIHVVMVEIKKYKSNY 662
               ||.|:|.||:|||::|..|
 Worm   681 VCSQLVNVHQVMLEIKRFKPAY 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps52	NP_608931.1	Vps52	42..546	CDD:282044	185/520 (36%)
vps-52	NP_509282.4	Sec3_C	64..554	CDD:303102	180/489 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156071
Domainoid	1	1.000	343	1.000	Domainoid score	I566
eggNOG	1	0.900	-	-		E1_KOG1961
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5756
Inparanoid	1	1.050	423	1.000	Inparanoid score	I995
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54348
OrthoDB	1	1.010	-	-		D139156at33208
OrthoFinder	1	1.000	-	-		FOG0003722
OrthoInspector	1	1.000	-	-		oto18698
orthoMCL	1	0.900	-	-		OOG6_101848
Panther	1	1.100	-	-	LDO	PTHR14190
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1656
SonicParanoid	1	1.000	-	-		X3644
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840