DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mid and TBX4

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_011523792.1	Gene:	TBX4 / 9496	HGNCID:	11603	Length:	609	Species:	Homo sapiens

Alignment Length:	494	Identity:	157/494 - (31%)
Similarity:	225/494 - (45%)	Gaps:	97/494 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 QSPGTEDSEERL--------------TPEPVQKAPKIVGSC-------NCD---------DLKPV 186
            |..|..:|||..              .|||...||.:.|:.       ..|         .::.:
Human    66 QDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENI 130

  Fly   187 QCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYR 251
            :..|..||||.:||:.||||||||.||||||:.:|..:|    :.|..:|.:|:||:|.|..||:
Human   131 KVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTG----MNPKTKYILLIDIVPADDHRYK 191

  Fly   252 YAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHR 316
            :..::  |:|||||:||.|.|||.|||||.:.....:|::||:|:|||||.:|..|.|:|||||:
Human   192 FCDNK--WMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHK 254

  Fly   317 YQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 381
            ||||:|:|:.....:..|     ::....|:|||||.|.:||:|||..||:|||::||||||||.
Human   255 YQPRLHIVKADENNAFGS-----KNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRG 314

  Fly   382 S-------SRLTDFDRDPMEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMF 439
            |       :||...:...:...::.|:|.||          |.:|..|...:....:|.||.|
Human   315 SDDSDLRVARLQSKEYPVISKSIMRQRLISP----------QLSATPDVGPLLGTHQALQHYQ-- 367

  Fly   440 GGNSPYAQLMMPQ---------------MYQAAAAAAGPP------------PPPPGLGAFHMFQ 477
            ..|..::||..||               .|......|...            ..|..:|..|.|:
Human   368 HENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKRSYLEAPSSVGEDHYFR 432

  Fly   478 QQWPQLTAGFLASANQQAAAAQAAAQAQAQAQAAAAAMAANRTPPPPPTASTPSSTS--SGSPSP 540
            .. |......|:.:.......:.|..........|.....:..||||.:.:..:|.|  :.....
Human   433 SP-PPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQ 496

  Fly   541 DMRPRQYQRFSPY-----QLPGGQGPPSSAAGSPPAVNA 574
            .|....||.|..:     .:|  :.|..||..|.|..||
Human   497 TMETVPYQPFPTHFTATTMMP--RLPTLSAQSSQPPGNA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	99/205 (48%)
TBX4	XP_011523792.1	TBOX	129..318	CDD:238106	99/199 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740