DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mid and TBX18

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001073977.1	Gene:	TBX18 / 9096	HGNCID:	11595	Length:	607	Species:	Homo sapiens

Alignment Length:	483	Identity:	181/483 - (37%)
Similarity:	233/483 - (48%)	Gaps:	74/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NSGGAVAQTASAESQLNTSST----SSQGRC-------STPPQSPG--TEDSEERL-----TPEP 167
            :.|.|:...|.|.|....|..    .:.|.|       ::|..|||  .:.|..|.     ||.|
Human    70 DEGAALPPPAGATSGPARSGADLERGAAGGCEDGFQQGASPLASPGGSPKGSPARSLARPGTPLP 134

  Fly   168 VQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQP 232
            ..:||::              .|:..|||.|||::||||||||.||||||.:||..||    :.|
Human   135 SPQAPRV--------------DLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISG----LDP 181

  Fly   233 ADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVK 297
            ..:|.:.|||:|:|:|||||.||.|.|:|||.||...|.|:|.|||||.|.|...:|||||:|:|
Human   182 HQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLK 246

  Fly   298 LTNNEMDKNGQIVLNSMHRYQPRIHLVRLSHGQSI-PSNPKELQDLDHKTYVFPETVFTAVTAYQ 361
            |||||:|..|.|:|:|||:||||:|::|...|..: |..|....: ..|.:.|||||||.|||||
Human   247 LTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGE-GVKAFSFPETVFTTVTAYQ 310

  Fly   362 NQLITKLKIDSNPFAKGFRDSSRLTDFDRDPMEALLLEQQL-RSPLRLFPDPLMQQFAAQGDPSS 425
            ||.||:||||.||||||||||.|    :|..:|||:..... |..||......:.....||:.||
Human   311 NQQITRLKIDRNPFAKGFRDSGR----NRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNASS 371

  Fly   426 MALFEKARQHLQMFGGNSPYAQLMMPQMYQAAAAAAGPPPPPPGLGAFHMFQQQWPQLTAGFLAS 490
            ..|       ||..|...|...   |.:...::.::         .|||: .....||.:  ||.
Human   372 STL-------LQGTGNGVPATH---PHLLSGSSCSS---------PAFHL-GPNTSQLCS--LAP 414

  Fly   491 ANQQAAAAQAAAQAQAQAQAAAA----AMAANRTPPPPPTASTPSSTSSGSPSPDMRPRQYQRFS 551
            |:..|.|.......:.....|..    ...|..|..||.|.|....:||.|.:..|.......||
Human   415 ADYSACARSGLTLNRYSTSLAETYNRLTNQAGETFAPPRTPSYVGVSSSTSVNMSMGGTDGDTFS 479

  Fly   552 PYQLP-----GGQGPPSSAAGSPPAVNA 574
            ..|..     .|..|........|:.||
Human   480 CPQTSLSMQISGMSPQLQYIMPSPSSNA 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	115/199 (58%)
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..141		19/70 (27%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		TBOX	139..334	CDD:238106	117/217 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820