Protein Alignment mid and EOMES

DIOPT Version :9

• Sequence 1: NP_001260096.1
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001265111.1
• Gene: EOMES / 8320
• HGNCID: 3372
• Length: 705
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 178/719 - (24%)
• Similarity: 243/719 - (33%)
• Gaps: 263/719 - (36%)

  Fly    10 CNGVPAAPAAPNASGQTTTTASKSAAGSATDFSIAAIMAREDASSRESSIRSASPISVEDEVDVD 74
            |..|...|||.:| |......|.:.||.|  |:.||.:|:......    |..||
Human    61 CEAVSGEPAAASA-GAPAAMLSDTDAGDA--FASAAAVAKPGPPDG----RKGSP---------- 108

  Fly    75 VVDCSDAEEPPTKARRLNHHQHHQHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTS 139
               |.:.|.|...|                                 :..|.|..|:|.::.:..
Human   109 ---CGEEELPSAAA---------------------------------AAAAAAAAAAATARYSMD 137

  Fly   140 STSSQGRCSTPPQSPGTEDSEE----RLTP---------EPVQKAPK------------------ 173
            |.||:....   ||||.:.||.    .|.|         .||..||.
Human   138 SLSSERYYL---QSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAA 199

  Fly   174 ------------------------------------------------IVGSCNCDDLKPV---- 186
                                                            ..|||.  .|..:
Human   200 VCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCG--GLGGLGVPG 262

  Fly   187 -----QCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMD 246
                 ..:|..:.||.:||...|||||||.||||||.:..:.:|    :.|...|.|.::::..|
Human   263 SGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNING----LNPTAHYNVFVEVVLAD 323

  Fly   247 SKRYRYAYHRSAWLVAGKADPAPPA-RLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNG--- 307
            ...:|  :....|:..||||..... ::|.||:||.:.....:|.|||.|:|||||:...|.
Human   324 PNHWR--FQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQ 386

  Fly   308 QIVLNSMHRYQPRIHLVRLSH-GQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKID 371
            .|||.|:|:||||:|:|.::. |....:.|.:.|     |:.|.||.|.|||||||..||:||||
Human   387 MIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQ-----TFTFSETQFIAVTAYQNTDITQLKID 446

  Fly   372 SNPFAKGFRDS--SRLTDFDRDPMEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQ 434
            .|||||||||:  |..|..:.|               ||.|.|       ...|.|..:....|.
Human   447 HNPFAKGFRDNYDSMYTASEND---------------RLTPSP-------TDSPRSHQIVPGGRY 489

  Fly   435 HLQMF---------------GGNSPYAQ---LMMPQMYQAAAAAAGP------PPPPPGLGAFHM 475
            .:|.|               .|.....|   |:.||  |:...|..|      |...||.....:
Human   490 GVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQ--QSEEVANPPQRWLVTPVQQPGTNKLDI 552

  Fly   476 --FQQQWPQLTA---GFLASANQQA------------AAAQAAAQAQAQAQAAAAAMAANRTPP- 522
              ::.::...|.   |..:...|.:            |.|....:...|.:.||.....:||.|
Human   553 SSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPT 617

  Fly   523 ----------------------PPPTASTPSSTSSGSPSPDMRPRQYQRFSPYQLPGGQGPPSSA 565
                                  .||:..:..|..||..:...:.|   |.||..        ||.
Human   618 VFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRR---RLSPSN--------SSN 671

  Fly   566 AGSP 569
            ..||
Human   672 ENSP 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	86/214 (40%)
EOMES	NP_001265111.1	TBOX	267..460	CDD:238106	86/203 (42%)
		T-box_assoc	482..703	CDD:292794	38/207 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740