DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mid and tbx21

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001164070.1	Gene:	tbx21 / 797797	ZFINID:	ZDB-GENE-080104-3	Length:	609	Species:	Danio rerio

Alignment Length:	584	Identity:	160/584 - (27%)
Similarity:	233/584 - (39%)	Gaps:	159/584 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 HQHHHNNNNNNNNNNVA--------HKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTPPQSPGT 156
            |..||.:.........|        ..||:..|.....|.|::.     :|:.|:...|..:.|.
Zfish    67 HAEHHQSAGAQTGRFYAPAPLGSCHFTSRSGTGHTYVPAGADAY-----SSANGKDVYPSSADGY 126

  Fly   157 EDSEERLTPE-PVQKAP--KIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPT 218
            ..|.:...|. |:...|  ::.|.        .|..|....||.:||...|||||||.||||||.
Zfish   127 TASFQHGFPRAPMYSLPGLQVSGK--------TQVLLNNYPLWAKFHKYQTEMIITKQGRRMFPF 183

  Fly   219 VRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPA-RLYAHPDSPFS 282
              :||:  :..:.|:..|.:.:|::..|...:|  |....|:..|||:...|. |:|.|||||.:
Zfish   184 --LSFN--ITSLDPSAHYNIYVDVVLADQHHWR--YQGGKWVQCGKAEGNMPGNRMYMHPDSPNT 242

  Fly   283 CEALRKQVISFEKVKLTNNEMDKNG---QIVLNSMHRYQPRIHLVRLSH-GQSIPSNPKELQDLD 343
            .....:|.:||.|:|||||:...|.   .|||.|:|:||||:|:|.:.. |...|....:.|
Zfish   243 GTHWMRQEVSFGKLKLTNNKGSSNNVAQMIVLQSLHKYQPRLHIVEVKEDGTEDPFLTSKTQ--- 304

  Fly   344 HKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS----------SRLTDFDRDPMEAL-- 396
              |:|||||.|.|||||||..||:||||.|||||||||:          .|||....:..:.|
Zfish   305 --TFVFPETQFIAVTAYQNADITQLKIDHNPFAKGFRDNYDTLYAPPDPDRLTPSPTESQQLLSG 367

  Fly   397 -------LLEQQLRSPL---RLFP-DPLMQQFAAQGDPSSMALFEKARQHLQMFGGNSPYAQLMM 450
                   .|..|..|||   |.:. :|:........||:|                 ||::
Zfish   368 SCYPHQPYLSDQYMSPLPQSRFYSREPVSMTQPCPKDPTS-----------------SPHS---- 411

  Fly   451 PQMYQAAAAAAGPPPPPPGLGAFHMFQQQWPQ------------------------LTAGFLASA 491
             :.|.::..|.     ||....|..::.::..                        .|:|.::||
Zfish   412 -RWYLSSQQAV-----PPNRLDFSAYETEYTSNSLYKPFPLQSSPHHPLSYYSENPFTSGAVSSA 470

  Fly   492 NQQAAAAQAAAQAQ----AQAQAAAAAMAANRTPPPPPTASTPSSTSS---GSPS---PDMRP-- 544
            |..|..|......|    .......::::..|..|.|..:|:|::|:|   .|||   |..:|
Zfish   471 NPGAWTASGRPSPQYLNHPHHSKPTSSLSWFRAVPSPAASSSPTATNSRFHASPSLLEPQRQPLL 535

  Fly   545 ---------------------------------RQYQRFSPYQLPGGQGPPSSAAGSPPAVNAS 575
                                             .:.:|.|||.......||:.:|.:....|.|
Zfish   536 QDKSKESTEDTWIEAPSVKSVDSADSGLFEGGESKKRRVSPYTSSTENSPPNRSAETCEKDNCS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	92/213 (43%)
tbx21	NP_001164070.1	TBOX	150..343	CDD:238106	92/211 (44%)
tbx21	NP_001164070.1	T-box_assoc	363..608	CDD:292794	47/264 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574499
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740