Protein Alignment mid and Tbx18

DIOPT Version :10

• Sequence 1: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_076303.3
• Gene: Tbx18 / 76365
• MGIID: 1923615
• Length: 613
• Species: Mus musculus
• Alignment Length: 613
• Identity: 202/613 - (32%)
• Similarity: 272/613 - (44%)
• Gaps: 163/613 - (26%)

  Fly    41 FSIAAIMAREDASSRESSIRSASPISVEDEVDVDVVD-------------CSDAEE----PPTKA 88
            ||:.|::..|.....:...|..:    .:|....|.|             ||:|:|    ||..|
Mouse    20 FSVEALIGAEKQQQLQKKRRKLA----TEEAAGAVEDAGCSRSGGAGEHGCSEADEEAAAPPPAA 80

  Fly    89 RRLNHHQHHQHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTA--SAESQLNTSSTSSQGRC---- 147
                                               ||.:..|  .|:::.:..|..:.|.|
Mouse    81 -----------------------------------GAASGPARSCADAERSCGSRGAAGSCEDGF 110

  Fly   148 ---STPPQSPGTEDSEERL-------TPEPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDL 202
               ::|..|||.......:       ||.|..:||::              .|:..|||.|||::
Mouse   111 LQGASPLASPGGSPKGSPVPGLARPGTPLPAPQAPRV--------------DLQGAELWKRFHEI 161

  Fly   203 GTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADP 267
            ||||||||.||||||.:||..||    :.|..:|.:.|||:|:|:|||||.||.|.|:|||.||.
Mouse   162 GTEMIITKAGRRMFPAMRVKISG----LDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS 222

  Fly   268 APPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIHLVRLSHGQSI 332
            ..|.|:|.|||||.|.|...:|||||:|:||||||:|..|.|:|:|||:||||:|::|...|..:
Mouse   223 PVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDL 287

  Fly   333 -PSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDRDPMEAL 396
             |..|....: ..|.:.|||||||.|||||||.||:||||.||||||||||.|    :|..:|||
Mouse   288 SPIKPVPSGE-GVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGR----NRMGLEAL 347

  Fly   397 LLEQQL-RSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMFGGNSPYAQLMMPQMYQAAAAA 460
            :..... |..||......:.....||:.||.||       ||..|...|...   |.:...::.:
Mouse   348 VESYAFWRPSLRTLTFEDIPGIPKQGNTSSSAL-------LQGTGNAVPATH---PHLLSGSSCS 402

  Fly   461 AGPPPPPPGLGAFHMFQQQWPQLTAGFLASANQQAAAAQAAA-----QAQAQAQAAAAAMAANRT 520
            :         .|||: .....||.:  ||.|:..|.|....|     .:.|:..:.....::...
Mouse   403 S---------PAFHL-GPNTSQLCS--LAPADYSACARSGLALNRYSTSLAETYSRLTNQSSETF 455

  Fly   521 PPPPPTASTPSSTS-SGSPSPDMR-----------PR-----QYQRFSP---YQLPGGQGPPSSA 565
            .||    .|||..| |.:||.:|.           |:     |....||   |.:|...|...:|
Mouse   456 APP----RTPSYVSVSSNPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSGNAFAA 516

  Fly   566 ------------AGSPPAV---NASRSP 578
                        ..||.|:   |.|.||
Mouse   517 NQTHQSSYNTFRLHSPCALYGYNFSTSP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	113/196 (58%)
Tbx18	NP_076303.3	Engrailed homology 1 repressor. /evidence=ECO:0000305|PubMed:17584735	18..28		3/7 (43%)
		Nuclear localization signal. /evidence=ECO:0000305|PubMed:17584735	36..40		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..94		15/95 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..145		7/30 (23%)
		T-box_TBX18_like	142..336	CDD:410325	114/212 (54%)